Method for the treatment of periodontal disease by sustained delivery of a therapeutic agent to the periodontal pocket, and composition of matter therefor
November 22, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3887699 Method of producing microcapsules and resulting product Microencapsulation process Process for preparation of microcapsules Microencapsulation of water soluble active polypeptides Local delivery of chemotherapeutic agents for the treatment of periodontal disease Active/passive immunization of the internal female reproductive organs Intra-pocket drug delivery devices for treatment of periodontal diseases Controlled release drug delivery system for the periodontal pocket Prolonged release microcapsules InventorsAssigneeApplicationNo. 706327 filed on 05/28/1991US Classes:424/426, Errodable, resorbable, or dissolving264/4.3, With treatment subsequent to solid wall formation (e.g., coating, hardening, etc.)264/4.6, Solid-walled microcapsule formed by physically removing a constituent (e.g., evaporation, extraction, etc.)424/423, Surgical implant or material424/435, Mouth424/486, Synthetic polymer424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)427/213.32, Hardening427/213.36, Solid-walled microcapsule formed from preformed synthetic polymer514/900, Periodontitis514/951, POWDERS, GRANULES OR PARTICLES OF SPECIFIED MESH OR PARTICLE SIZE514/963Microcapsule-sustained or differential releaseExaminersPrimary: Kishore, G. S.Assistant: Spear, James M. Attorney, Agent or FirmInternational ClassesA61K 006/00A61K 009/52 AbstractOral compositions for the local administration of a therapeutic agent to a periodontal pocket of a patient for alleviating dental disease comprise a plurality of dry, discrete microparticles each of which comprise an effective amount of at least one therapeutic agent dispersed in a matrix comprising a biocompatible and biodegradable polymer. Apparatus and methods are also provided for the dispensing of the dry microparticles to the periodontal pocket whereby they become tacky and adhere to the involved tissue so as to induce long term therapeutic benefits. | |
