U.S. patents available from 1976 to present.
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Silicone vesicles and entrapment

Patent 5364633 Issued on November 15, 1994. Estimated Expiration Date: Icon_subject March 14, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Large unilamellar vesicles (LUV) and method of preparing same
Patent #: 4078052
Issued on: 03/07/1978
Inventor: Papahadjopoulos

Method for an effective moisturizing treatment of the skin, particularly useful in cosmetics applications
Patent #: 5106624
Issued on: 04/21/1992
Inventor: Bertini

Process for the preparation of dispersible colloidal systems of a substance in the form of nanoparticles
Patent #: 5133908
Issued on: 07/28/1992
Inventor: Stainmesse, et al.

Paucilamellar lipid vesicles
Patent #: 5147723
Issued on: 09/15/1992
Inventor: Wallach

Spontaneous equilbrium surfactant vesicles
Patent #: 5165994
Issued on: 11/24/1992
Inventor: Kaler, et al.

Surface-modifiable liposome and process for producing surface-modified liposome Patent #: 5190822
Issued on: 03/02/1993
Inventor: Nishikawa, et al.

Inventors

Assignee

Application

No. 212753 filed on 03/14/1994

US Classes:

424/450, Liposomes264/4.1, Liquid encapsulation utilizing an emulsion or dispersion to form a solid-walled microcapsule (includes liposome)424/59, TOPICAL SUN OR RADIATION SCREENING, OR TANNING PREPARATIONS424/64, Lip424/76.1, DEODORANTS (NONBODY)428/402.2, Microcapsule with fluid core (includes liposome)514/841, CONTRACEPTIVE514/844, COSMETIC, FACIAL521/76Preparing a cellular product utilizing a stated ingredient which is surface coated or is a discrete solid particle containing a fluid encapsulated therein, processes of forming an expandible composition, containing said stated ingredient or composition therefrom

Examiners

Primary: Foelak, Morton

Attorney, Agent or Firm

International Classes

A61K 009/51
A61K 037/22

Abstract

A method of entrapping a water-soluble substance in vesicles formed from a siloxane surfactant is carried out by dissolving the substance to be entrapped in water, adding a siloxane surfactant, mildly agitating the mixture, and removing excess of water and substance. Water-insoluble substances can be entrapped in the vesicles by dissolving the substance to be entrapped in the siloxane surfactant, and mildly agitating the substance and the siloxane surfactant. Suitable siloxane surfactants are R--[Si(Me)2 O]14 --Si(Me)2 --R in which R is --(CH2)3 (OCH2 CH2)7 OH, R--[Si(Me)2 O]14 --Si(Me)2 --R in which R is --(CH2)3 (OCH2 CH2)12 OH, Me3 SiO[Si(Me)2 O]22 --[SiMeRO]2 --SiMe3 in which R is --(CH2)3 (OCH2 CH2)12 OH, and Me3 SiO[Si(Me)2 O]103 --[SiMeRO]10 --SiMe3 in which R is --(CH2)3 (OCH2 CH2)12 OH.

Other References

  • Handjani-Vila R. M.; Int. J. Cosmetic Sci., 1(1979)303, "Dispersions of lamellar phases of nonionic lipids in cosmetic products"
  • Lautenschlager, H.; Cosmetic & Toiletries, 105(1990)89, "Liposomes in dermatological preparations Part I"
  • Lautenschlager, H.; Cosmetic & Toiletries, 105(1990)63, "Liposomes in dermatological preparations Part II"
  • Hill, R. M.; Mixed Surfactant Systems, ACS Symp. Ser., 501(1992)278, "Interactions between siloxane surfactants and hydrocarbon surfactants"
  • Suzuki, K.; Cosmetics & Toiletries, 105(1990)65, "The Application of liposomes to Cosmetics"
  • Strauss, G. J.; J. Soc. Cosmet. Chem., 40(1989)51, "Liposomes: from theoretical model to cosmetic tool"
  • Mitchell, D. J.; J. C. S. Faraday Trans, 2,77(1981)601, "Micelles, vesicles and microemulsions"
  • Israelachvili, J. N.; J. C. S. Faraday Trans 2,72(1976)1525, "Theory of self-assembly of hydrocarbon amphiphiles into micelles and bilayers"
  • Hill, R. M.; Langmuir, 9(1993)2789, "Lyotropic liquid crystal phase behaviro of polymeric siloxane surfactants"
  • Talsma, H.; BioPharm, Oct. (1992)36, "Liposomes as drug delivery systems, part I: preparation.
  • Talsma, H., Pharmaceutical Technology; Nov. (1992)53, "Liposomes as drug delivery systems, part II: Characterization"
  • Talsma, H.; Pharmaceutical Technology, Jan. (1993)36, "Liposomes as drug delivery systems, part III: Stabilization
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