Method for treating asthma using optically pure (R)-albuterol

Patent 5362755 Issued on November 8, 1994. Estimated Expiration Date:

December 7, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Inventors

Assignee

Sepracor Inc.

Application

No. 163581 filed on 12/07/1993

US Classes:

514/649, Amino nitrogen attached to aryl ring or aryl ring system by an acyclic carbon or acyclic chain514/826ASTHMA

Examiners

Primary: Henley, III, Raymond

Attorney, Agent or Firm

Heslin & rothenberg

Foreign Patent References

2255503 GB. 07/13/1992

International Class

A61K 031/135

Abstract

The optically pure R(-) isomer of albuterol, which is substantially free of the S(+) isomer, is a potent bronchodilator for relieving the symptoms associated with asthma in individuals. A method is disclosed utilizing the optically pure R(-) isomer of albuterol for treating asthma while minimizing the side effects associated with chronic administration of racemic albuterol.

Other References

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D. Hartley and D. Middlemiss, J. Med. Chemistry, 14(9):895 (1971)
C. K. Buckner and P. Abel, J. Pharmacol. Exp. Ther., 189(3):616-625 (1974)
Tan et al., "Analysis of Salbutomol Enantiomers in Human Urine by Chiral High Performance Liquid Chromatography and Preliminary Studies Related to the Stereoselective Disposition Kinetics in Man", J. Chromatogr., 422, 187-95 (1987)
Chemical Abstracts 89:123259m (1978