Biocompatible metal surfaces
November 3, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3549409 3585647 3639141 3826678 Process for providing enzyme activity to a solid surface Covalent bonded antithrombogenic polyurethane material Conjugates of anticoagulant and protein Process for the production of built-up films by the stepwise adsorption of individual monolayers Apparatus and method for applying a silicon oxide-containing adhesion-promoting layer on metallic dental prostheses Conjugates of anticoagulant and protein InventorsApplicationNo. 147017 filed on 11/03/1993US Classes:424/422, Implant or insert424/423, Surgical implant or material427/2.24, Implantable permanent prosthesis (i.e., artificial body member) (e.g., pacemaker, lens, cornea, glaucoma shunt, heart valve, muscle, spinal disc, breast, internal organ)623/1.42, Drug delivery623/900, STENT FOR HEART VALVE623/901METHOD OF MANUFACTURING PROSTHETIC DEVICEExaminersPrimary: Green, Randall L.Assistant: Nguyen, Dinh Q. Attorney, Agent or FirmForeign Patent References
International ClassesA61F 002/02A61F 002/06 A61F 002/24 A61F 002/76 AbstractMetallic surfaces of medical devices or components of medical devices are provided that have enhanced biocompatibility properties. The surfaces are prepared by a two-step procedure including covalently linking an organosilane having amine reactive sites with the surface of the metallic member, typically through a metal oxide thereof. Thereafter, a biologically active agent is covalently linked to the organosilane coating. The two-step process is particularly advantageous for preparing medical devices in the form of stents which need to be bent and flexed during implantation procedures. | |
