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Examination of subjects using photon migration with high directionality techniques

Patent 5353799 Issued on October 11, 1994. Estimated Expiration Date: Icon_subject June 17, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Imaging process and system for transillumination with photon frequency marking
Patent #: 5174298
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Inventor

Assignee

Application

No. 900197 filed on 06/17/1992

US Classes:

600/473, Infrared radiation356/319, Utilizing a spectrophotometer (i.e., plural beam)600/476Visible light radiation

Examiners

Primary: Sykes, Angela D.

Attorney, Agent or Firm

International Class

A61B 005/00

Abstract

A method and system for examination of a subject positioned between input and detection ports of the spectroscopic system applied to the subject. The systems shown include at least one light source for introducing at one or multiple input ports, electromagnetic non-ionizing radiation of a known time-varying pattern of photon density of a wavelength selected to be scattered and absorbed while migrating in the subject, radiation pattern control means for achieving a directional pattern of emitted resulting radiation that possesses substantial gradient of photon density, at least one detector for detecting the radiation that has migrated in the subject at one or multiple detection ports. The systems also include processing means for processing the detected radiation and creating sets of data, and evaluation means for examining the subject using the data sets. The emitted directional radiation pattern utilizes its gradient of photon density to detect a hidden object while scanning across the examined subject. The wavelength of the radiation can be selected to be sensitive to endogenous or exogenous pigments, or to cause fluorescent emission from a fluorescent constituent of interest in the subject. The operation of the systems is computer controlled.

Other References

  • Oda et al., "Non-Invasive Hemoglobin Oxygenation Monitor and Computerized Tomography of NIR Spectrometry," SPIE, vol. 1431, p. 284, 1992
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  • Y. Yamashita et al., "The Neonate Brain (NIR) and Breast Imaging Using Transillumination" Photon Migration in Tissues, p. 55, Plenum Press, New York 1989
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  • Cui, et al., "Experimental Study Of Migration Depth For The Photons Measured At Sample Surface" SPIE, vol. 1431 (1991) p. 180
  • Barlow, et al., "Breast Biopsy Analysis By Spectroscopic Imaging" p. 111, Plenum Press, New York 1989
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  • Sevick, et al., "Photon migration in a model of the head measured using time-and-frequency-domain techniques potentials of spectroscopy and imaging" SPIE, vol. 1431, (1991) p. 8
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