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Injectable ceramic compositions and methods for their preparation and use

Patent 5352715 Issued on October 4, 1994. Estimated Expiration Date: Icon_subject August 2, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Inductive collagen based bone repair preparations
Patent #: 4563350
Issued on: 01/07/1986
Inventor: Nathan ,   et al.

Surgical cement from amorphous tricalcium phosphate, poly(carboxylic acid) and water
Patent #: 4684673
Issued on: 08/04/1987
Inventor: Adachi

Preparation of collagen hydroxyapatite matrix for bone repair
Patent #: 4776890
Issued on: 10/11/1988
Inventor: Chu

Xenogeneic collagen/mineral preparations in bone repair
Patent #: 4795467
Issued on: 01/03/1989
Inventor: Piez ,   et al.

Injectable implant composition having improved intrudability
Patent #: 4803075
Issued on: 02/07/1989
Inventor: Wallace ,   et al.

Materials for implantation comprising a polyacrylate containing spherical tricalcium phosphate particles
Patent #: 4842603
Issued on: 06/27/1989
Inventor: Draenert

Injectable composition for inductive bone repair
Patent #: 4863732
Issued on: 09/05/1989
Inventor: Nathan ,   et al.

Gamma irradiation of collagen/mineral mixtures
Patent #: 4865602
Issued on: 09/12/1989
Inventor: Smestad ,   et al.

Method of making molds with xenogeneic collagen/mineral preparations for bone repair
Patent #: 4992226
Issued on: 02/12/1991
Inventor: Piez, et al.

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Inventors

Assignee

Application

No. 101333 filed on 08/02/1993

US Classes:

523/115, Composition suitable for use as tooth or bone replacement, restorative, or implant424/423, Surgical implant or material523/113, Composition suitable for use as tissue or body member replacement, restorative, or implant524/415, Atom other than P, O, H, or a metal524/417Phosphorus atom directly bonded to four oxygen atoms, e.g., phosphoric acid, etc.

Examiners

Primary: Michl, Paul R.
Assistant: DeWitt, LaVonda R.

Attorney, Agent or Firm

International Classes

A61F 002/00
C08K 003/32
A61M 031/00

Abstract

Injectable implant compositions comprise a biocompatible ceramic matrix present in a fluid carrier, where the ceramic matrix comprises particles having a size distribution in the range from 50 μm to 250 μm. Optionally, the compositions may further comprise collagen, where the relative amounts of collagen and ceramic matrix at least partly determine the physical properties of implants formed by injecting the compositions. The fluid carrier is an aqueous buffered medium, typically including an organic polymer base material when there is no collagen present in the composition. The compositions are particularly suitable for repair and augmentation of soft and hard tissues by injection.

Other References

  • Lemons et al. Second World Congress of Biomaterials, Apr. 27-May 1, 1984
  • Polytef.RTM. Paste (Mentor Corporation, Santa Barbara, Calif.) 2 page description
  • Hench, "Bioglass Implants for otology," in: Biomaterials in Otology, Grote, ed., pp. 62-69, Martinus Nijhoff Publ. (1983
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