U.S. patents available from 1976 to present.
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Method for the treatment of chronic pain

Patent 5352683 Issued on October 4, 1994. Estimated Expiration Date: Icon_subject March 5, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Method and composition of reducing pain
Patent #: 4316888
Issued on: 02/23/1982
Inventor: Nelson

Iontophoresis intermediary material and contact solution for the treatment of chronic pain syndromes
Patent #: 4602909
Issued on: 07/29/1986
Inventor: Csillik ,   et al.

Method of treating patients suffering from chronic pain or chronic cough
Patent #: 4769372
Issued on: 09/06/1988
Inventor: Kreek

Method of treating patients suffering from chronic pain or chronic cough
Patent #: 4785000
Issued on: 11/15/1988
Inventor: Kreek ,   et al.

(3S-4S)-7-hydroxy-Ɗ6 -tetrahydrocannabinols
Patent #: 4876276
Issued on: 10/24/1989
Inventor: Mechoulam, et al.

Treating autism and other developmental disorders in children with NMDA receptor antagonists
Patent #: 4994467
Issued on: 02/19/1991
Inventor: Zimmerman

Method for relieving chronic pain with a somatostatin analog composition
Patent #: 5006510
Issued on: 04/09/1991
Inventor: Ellis

Using NMDA receptor antagonists to reduce damage due to laser treatment
Patent #: 5013540
Issued on: 05/07/1991
Inventor: Redburn

Sialosyl cholesterol, process for producing the same, and neuropathy remedy comprising the same
Patent #: 5023239
Issued on: 06/11/1991
Inventor: Ogura, et al.

Tetrazole derivatives and aldose reductase inhibition therewith
Patent #: 5055481
Issued on: 10/08/1991
Inventor: Inukai, et al.

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Inventors

Assignee

Application

No. 027177 filed on 03/05/1993

US Classes:

514/289, Two of the cyclos share at least three ring members (i.e., bridged) (e.g., morphinans, etc.)514/647Amino nitrogen and a ring bonded directly to the same ring and any other amino nitrogen in the compound is bonded directly to one of the rings

Examiners

Primary: Cintins, Marianne M.
Assistant: Jarvis, William R. A.

Attorney, Agent or Firm

International Class

A61K 031/485

Abstract

Chronic pain is alleviated in a mammal suffering therefrom by administering to the mammal a chronic pain alleviating amount of a nontoxic N-methyl-D-aspartate receptor antagonist such as dextromethorphan, dextrorphan, ketamine or pharmaceutically acceptable salt thereof, alone or in combination with a local anesthetic and optionally in sustained release dosage form.

Other References

  • Hayes et al., "Pretreatment with gangiolsides reduces abnormal nociceptive responses associated with a rodent peripheral mononeuropathy", Pain, 48 (1992) 391-396
  • Mao et al., "Post-injury treatment with GM1 ganglioside reduces nociceptive behaviors and spinal cord metabolic activity in rats with experimental peripheral mononeuropathy", Brain Research, 584 (1992) 18-27
  • Mao et al., "Intrathecal GM1 ganglioside and local nerve anesthesia reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy", Brain Research, 584 (1992) 28-35
  • Mao et al. "Pain-related increases in spinal cord membrane-bound protein kinase C following peripheral nerve injury", Brain Research, 588 (1992) 144-149
  • Mao et al., Brain Research, 576 (1992) 254-26
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