Surfactant-stabilized microbubble mixtures, process for preparing and methods of using the same
November 22, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesCarrier liquid solutions for the production of gas microbubbles, preparation thereof, and use thereof as contrast medium for ultrasonic diagnostics Particulate NMR contrast agents for gastrointestinal application Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures Inverse emulsion polymerization with sorbitan fatty acid esters and ethoxylated alcohol Ultrasonic imaging agent and method of preparation Contrast medium for ultrasonic examinations and process for its preparation Concentrated stabilized microbubble-type ultrasonic imaging agent Continuous sonication method for preparing protein encapsulated microbubbles Patent #: 4957656 InventorsAssigneeApplicationNo. 162421 filed on 11/22/1993US Classes:424/9.52, Stable gas bubbles containing or intentional solubilized gas containing600/438Used as an indicator of another parameter (e.g., temperature, pressure, viscosity)ExaminersPrimary: Raymond, Richard L.Attorney, Agent or FirmInternational ClassA61K 049/00AbstractThe present invention is a mixture including a solvent, a first surfactant and a second, dispersible surfactant different from the first surfactant, the mixture having stabilized gas microbubbles formed therein by sonication. The gas microbubbles are useful in ultrasonic diagnostics. Preferably the first surfactant is substantially soluble in the solvent and the second surfactant is substantially insoluble in the solvent. The present invention also includes a process for preparing the stabilized gas microbubbles and a method for altering the contrast of an ultrasonic image using the microbubbles as a contrast agent.Other References
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