Heteroanthracycline antitumor analogs
Patent 5348946 Issued on September 20, 1994. Estimated Expiration Date: 
September 20, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 20, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesHydraulic horizontal mixer Dimethylfurano heterocyclic analogs of daunomycin 1-fluoro, 4-fluoro, and 1,4-difluoro anthracycline anticancer antibiotics Process for producing 10-hydroxyanthracyclines Patent #: 4877870 Inventors
ApplicationNo. 751092 filed on 08/28/1991US Classes:514/34, Oxygen of the saccharide radical bonded directly to a polycyclo ring system of four carbocyclic rings (e.g., daunomycin, etc.)536/6.4, Daunomycin or derivative536/18.1Polycyclo ring system (e.g., hellebrin, etc.)ExaminersPrimary: Brown, Johnnie R.Assistant: Peselev, Elli Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/70C07H 015/24 AbstractHeterocyclic antitumor compounds are described, which are useful in the treatment of cancer and tumors in vitro, such as breast cancer, leukemia, lung cancer, colon cancer, ovarian cancer, renal cancer, CNS cancer and melanoma. Pharmaceutical compositions and method of preparing the compounds are also described.Other References
Field of SearchPolycyclo ring system (e.g., hellebrin, etc.)Oxygen of the saccharide radical bonded directly to a polycyclo ring system of four carbocyclic rings (e.g., daunomycin, etc.) Hetero ring is six-membered having two or more ring hetero atoms of which at least one is nitrogen (e.g., selenazines, etc.) Polycyclo ring system having the six-membered hetero ring as one of the cyclos Six-membered hetero ring consists of oxygen, nitrogen and carbon (e.g., 1,2-oxazines, etc) Anthrone or anthraquinone in the polycyclo ring system Polycyclo ring system having the diazine ring as one of the cyclos Tetracyclo ring system having the five-membered hetero ring as one of the cyclos Plural ring hetero atoms in the tetracyclo ring system The five-membered hetero ring shares ring members with one other cyclo only The hetero ring is six-membered Plural ring hetero atoms in the hetero ring Polycyclo ring system having the hetero ring as one of the cyclos Two ring sulfurs in the hetero ring The polycyclo ring system has at least four cyclos The hetero ring is five-membered Nitrogen or chalcogen attached indirectly to the hetero ring by nonionic bonding Oxygen containing hetero ring (e.g., dioxirane, etc.) The hetero ring is six-membered Plural ring oxygens in the hetero ring (e.g., 1,2-dioxin, etc.) The hetero ring is five-membered |
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