Pulsatile once-a-day delivery systems for minocycline
June 23, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3080294 3865935 Sustained release pharmaceutical composition Sustained release indomethacin Long acting preparation of cefalexin for effective treatments of bacterial infection sensitive to cefalexin Divisible tablet having controlled and delayed release of the active substance Pharmaceutical multiple-units formulation Controlled release tablet Pharmaceutical compositions in the form of beadlets and method Novel controlled release formulations of tetracycline compounds Inventors
AssigneeApplicationNo. 081632 filed on 06/23/1993US Classes:424/494, Cellulose derivatives424/458, Containing discrete coated particles pellets, granules, or beads424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)424/462, Containing solid synthetic polymers424/490, Coated (e.g., microcapsules)424/493, Containing polysaccharides (e.g., sugars)424/495, Ethyl cellulose424/497, Containing solid synthetic polymers424/498Containing waxes, higher fatty acids, higher fatty alcohols, or derivatives thereofExaminersPrimary: Page, Thurman K.Assistant: Spear, James M. Attorney, Agent or FirmInternational ClassesA61K 009/54A61K 009/56 A61K 009/58 AbstractPharmaceutical delivery systems containing 7-dimethyl-6-deoxy-6-demethyltetracycline or a non-toxic acid addition salt thereof comprising mixtures of a minor proportion of slow-release blended polymer coated spherical granules adapted to release part of the minocycline in a medium having a pH of below 3.9 and the rest in the range of from about 4.0 to about 7.5 and a major proportion of coated or uncoated quick-release granules adapted to release minocycline in a medium having a pH of less than about 3.9 and oral dosage unit form capsules containing the above are provided. These systems and formulations provide enhanced therapeutic blood levels of minocycline for at least about 24 hours when administered to a subject only once-a-day, regardless of whether the patient is fed or fasted. Methods for the preparation of the systems and formulations are provided as well.Other References
Field of SearchContaining discrete coated particles pellets, granules, or beadsContaining polysaccharide (e.g., cellulose sugars, etc.) Containing solid synthetic polymers Coated (e.g., microcapsules) Containing polysaccharides (e.g., sugars) Cellulose derivatives Ethyl cellulose Containing solid synthetic polymers Containing waxes, higher fatty acids, higher fatty alcohols, or derivatives thereof | |
