Microbeads of diltiazem, a process for their manufacture and a substained-release pharmaceutical composition containing them
Patent 5344657 Issued on September 6, 1994. Estimated Expiration Date: 
April 5, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 5, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesPharmaceutical compositions in the form of beadlets and method Controlled absorption diltiazem formulation for once-daily administration Controlled absorption diltiazem formulation Coating membrane and compositions prepared therefrom Patent #: 5149542 InventorAssigneeApplicationNo. 043592 filed on 04/05/1993US Classes:424/458, Containing discrete coated particles pellets, granules, or beads424/451, Capsules (e.g., of gelatin, of chocolate, etc.)424/459Organic coatingsExaminersPrimary: Page, Thurman K.Assistant: Benston, William E. Jr. Attorney, Agent or FirmForeign Patent References
International ClassA61K 009/54Foreign Application Priority Data1988-04-27 FRAbstractThe microbeads are composed of a core containing the active ingredient and a microporous membrane, insoluble in aqueous medium, consisting of a film-forming polymer, a plasticizer and a filling material.The membrane has a thickness such that diltiazem is released in vitro at an approximately constant rate for at least 6 hours after a latent period of less than one hour.The active ingredient can be intimately mixed with the core or included in a polyvinyl pyrrolidone layer coating an inert grain.The sustained-release microbeads are formed by application to the core of a dispersion of the constituents of the membrane in a solvent and evaporation of the solvent.The pharmaceutical compositions consist of capsules containing the microbeads. They are administered orally one or twice per day, depending on the dose, for the treatment of angina or hypertension. | |
