Patent References3652589 InventorsApplicationNo. 974865 filed on 11/10/1992US Classes:514/629, R is hydrogen or a lower saturated alkyl of less than seven carbons514/646Benzene ring containingExaminersPrimary: Waddell, Frederick E.Assistant: Jarvis, William R. A. Attorney, Agent or FirmInternational ClassA61K 031/165AbstractThis invention relates to a composition comprising a tramadol material and acetaminophen, and its use. As used herein tramadol refers to various forms of tramadol. The compositions are pharmacologically useful in treating pain and tussive conditions. The compositions are also subject to less opioid side-effects such as abuse liability, tolerance, constipation and respiratory depression. Furthermore, where the components of the compositions are within certain ratios the pharmacological effects of the compositions are superadditive (synergistic). | |