Formulations for nanoparticulate x-ray blood pool contrast agents using high molecular weight nonionic surfactants

Patent 5326552 Issued on July 5, 1994. Estimated Expiration Date:

December 17, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

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Inventors

Assignee

Sterling Winthrop Inc.

Application

No. 991909 filed on 12/17/1992

US Classes:

424/9.455, Carbonyl of a carboxylic acid or salt thereof attached directly to the benzene ring424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/499, Contains proteins or derivative or polysaccharides or derivative514/5, Iodine containing514/718, Plural oxygens514/975CHARACTERIZED BY THE DESIGNATED SURFACTANT USED

Examiners

Primary: Hollinden, Gary E.

Attorney, Agent or Firm

Davis; William J.

Foreign Patent References

498482 EP. 08/13/1992

International Classes

A61K 049/04
A61K 009/14
A61K 009/50

Abstract

The present invention is directed to a composition comprised of nanoparticles containing an X-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith.The present invention is still further directed to a method for diagnostic imaging for use in medical procedures comprising administering to the body of a test subject in need of an X-ray an effective contrast producing amount of a composition comprised of nanoparticles containing an X-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith.