Cyclodextrin/drug complexation

Patent 5324718 Issued on June 28, 1994. Estimated Expiration Date:

July 14, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3459731

Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives
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Inventor

Loftsson, Thorsteinn

Application

No. 912853 filed on 07/14/1992

US Classes:

514/58, Dextrin or derivative514/772.2, Polyvinyl alcohol514/772.3, Solid synthetic organic polymer514/772.6, Carboxylic acid containing monomer514/773, Peptide containing514/777, Carbohydrate or lignin, or derivative514/779, Algin or derivative514/781, Cellulose or derivative536/103Dextrin or derivative

Examiners

Primary: Griffin, Ronald W.

Attorney, Agent or Firm

Burns, Doane, Swecker & Mathis

Foreign Patent References

0213514 EP. 03/13/1987
0327766 EP. 08/13/1989
0149197 EP. 03/13/1990
472327 EP. 02/13/1992
466134 SE. 01/13/1992
91/04026 WO. 04/13/1991
92/09307 WO. 06/13/1992

International Classes

A61K 031/735
C08B 037/16

Abstract

The invention provides a method for enhancing the complexation of a cyclodextrin with a lipophilic and/or water-libile drug, comprising combining from about 0.1 to about 70% (weight/volume) of a cyclodextrin and from about 0.01 to about 5% (weight/volume) of a pharmaceutically acceptable, pharmacologically inactive, water-soluble polymer in an aqueous medium with a lipophilic and/or water-labile drug to form a drug complex, optionally followed by removal of water. Related methods, co-complexes of drug/cyclodextrin/polymer, pharmaceutical compositions and cyclodextrin/polymer complexing agents are also provided.

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