U.S. patents available from 1976 to present.
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Heat surgery system monitored by real-time magnetic resonance temperature profiling

Patent 5323779 Issued on June 28, 1994. Estimated Expiration Date: Icon_subject December 8, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Nuclear magnetic resonance imaging method
Patent #: 4554925
Issued on: 11/26/1985
Inventor: Young

In-vivo method for determining and imaging temperature of an object/subject from diffusion coefficients obtained by nuclear magnetic resonance
Patent #: 4914608
Issued on: 04/03/1990
Inventor: LeBihan, et al.

Hyperthermic power delivery system
Patent #: 4951688
Issued on: 08/28/1990
Inventor: Keren

Use of magnetic field of magnetic resonance imaging devices as the source of the magnetic field of electromagnetic transducers
Patent #: 5131392
Issued on: 07/21/1992
Inventor: Jolesz, et al.

Quantitative measurement of blood flow using cylindrically localized Fourier velocity encoding
Patent #: 5133357
Issued on: 07/28/1992
Inventor: Dumoulin, et al.

Method and apparatus for measuring temperature of subject
Patent #: 5207222
Issued on: 05/04/1993
Inventor: Koizumi, et al.

Magnetic resonance guided focussed ultrasound surgery Patent #: 5247935
Issued on: 09/28/1993
Inventor: Cline, et al.

Inventor

Application

No. 162987 filed on 12/08/1993

US Classes:

600/411, Combined with therapeutic or diverse diagnostic device600/412, Temperature detection600/549, Temperature detection601/2, Ultrasonic607/89, Laser application607/93Light pipe applicator

Examiners

Primary: Smith, Ruth S.

Attorney, Agent or Firm

International Class

A61B 005/055

Abstract

Surgery is performed with a pulsed heat-producing device that selectively heats a region in a specific tissue within a patient destroying the tissue. The pulsed heat-producing device may be a coherent optical source that is guided by laser fiber to the tissue to be destroyed. In another embodiment, the pulsed heat-producing device is a focussed ultrasound transducer which concentrates ultrasonic energy at a focal point within the specific tissue. A magnetic resonance imaging system employing a real-time temperature-sensitive pulse sequence monitors the heated region of the tissue to provide temperature profiles allowing an operator to alter the position and size of the heated region.

Other References

  • "MR Imaging Of Laser-Tissue Interactions", By F. A. Jolesz, A. R. Bleire, P. Jakob, P. W. Ruenzel, K. Huttl, G. J. Jako, Radiology 168:249-253 (1989)
  • "Effects Of Physical Parameters On High Temperature Ultrasound Hyperthermia" By B. E. Billard, K. Hynynen And Robert B. Roemer, Ultrasound In Med. & Biol., vol. 16, No. 4, pp. 409-419, 1990
  • "Thermal Diffusivity Of Isotopically Enriched 12C Diamond" By T. R. Anthony, W. F. Banholzer And J. F. Fleischer, Phys. Rev. B, vol. 42, No. 2, Jul. 15, 1990, pp. 1104-1111
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  • "Spatial Localization In Two Dimensions Using NMR Designer Pulses" By C. Hardy And H. Cline, J. Of Magnetic Resonance 82, 647-654 (1989)
  • "Correcting For Nonuniform-K-Space Sampling In Two-Dimensional NMR Selective Excitation" By C. Hardy, H. Cline And P. Bottomley, J. Of Magnetic Resonance 87, 639-645 (1990)
  • "Rapid NMR Cardiography With A Half-Echo M-Mode Method" By C. Hardy, et al., J. Of Computer Assisted Tomogr., vol. 15, No. 5 (1991) pp. 868-874
  • "MR-Guided Focused Ultrasound Surgery" By H. Cline, et al., J. Of Comp. Assist. Tomogr., vol. 16, No. 6 (1992), pp. 956-96
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