Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance

Patent 5321012 Issued on June 14, 1994. Estimated Expiration Date:

April 6, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

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Inventors

Assignee

Virginia Commonwealth University Medical College of Virginia

Application

No. 043280 filed on 04/06/1993

US Classes:

514/25, O-glycoside514/216, Two of the cyclos share at least three ring carbons (i.e., bridged)514/223.5, With additional active ingredient514/224.5, At least three cyclos in the polycyclo ring system514/225.5, The hetero ring is monocyclic piperidine514/231.2, Morpholines (i.e., fully hydrogenated 1,4- oxazines)514/282, One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)514/289, Two of the cyclos share at least three ring members (i.e., bridged) (e.g., morphinans, etc.)514/812, Narcotic536/53, Oxygen double bonded and nitrogen bonded directly to the same carbon536/55.1Polysaccharides

Examiners

Primary: Waddell, Frederick E.
Assistant: Criares, T. J.

Attorney, Agent or Firm

Dilworth & Barrese

International Classes

A61K 031/70
A61K 031/55
A61K 031/54
A61K 031/44

Abstract

Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA receptor activation, e.g., a ganglioside such as GM1 or GT1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e.g., narcotic analgesics such as morphine, codeine, etc.

Other References

Koyunchoglu et al., International Journal of Clinical Pharmacology, Therapy and Toxicology, vol. 28, No. 4 1990 (147-152), The treatment of heroin addicts with dextromethorphan: A double-bine comparison of dextromethorphan with chlorpromazine
Marek et al. Abstract No. 92034071, Brain-Res., Aug. 30, 1991 558(1). pp. 163-165
Marek et al. Abstract No. 91316632, Brain-Res., Apr. 26, 1991 547(1). pp. 77-81
Tanganelli et al. Abstract No. 91226742, Neurosci-Lett., Jan. 28, 1991 122(2). pp. 270-272
Trujillo et al. Abstract No. 91095981, Science, Jan. 4, 1991 251(4989). pp. 85-8