U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Transdermal formulations, methods and devices

Patent 5314694 Issued on May 24, 1994. Estimated Expiration Date: Icon_subject March 26, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3598122

3598123

Device consisting of copolymer having acetoxy groups for delivering drugs
Patent #: 4144317
Issued on: 03/13/1979
Inventor: Higuchi ,   et al.

Therapeutic system for administering drugs to the skin
Patent #: 4286592
Issued on: 09/01/1981
Inventor: Chandrasekaran

Dissolution controlled active agent dispenser
Patent #: 4314557
Issued on: 02/09/1982
Inventor: Chandrasekaran

Dosage for coadministering drug and percutaneous absorption enhancer
Patent #: 4379454
Issued on: 04/12/1983
Inventor: Campbell ,   et al.

Skin permeation enhancer compositions
Patent #: 4568343
Issued on: 02/04/1986
Inventor: Leeper ,   et al.

Skin permeation enhancer compositions using glycerol monolaurate
Patent #: 4746515
Issued on: 05/24/1988
Inventor: Cheng ,   et al.

Transdermal contraceptive formulations
Patent #: 4816258
Issued on: 03/28/1989
Inventor: Nedberge ,   et al.

Skin permeation enhancer compositions using glycerol monooleate Patent #: 4863738
Issued on: 09/05/1989
Inventor: Taskovich

Inventors

Application

No. 039593 filed on 03/26/1993

US Classes:

424/448, Pressure sensitive adhesive means424/447, Bandages with incorporated medicaments424/449, Transdermal or percutaneous514/946, PENETRANT OR ABSORBENT (ENHANCES PENETRATION INTO SUBJECT TREATED)514/947Topical application

Examiners

Primary: Phelan, D. Gabrielle

Attorney, Agent or Firm

Foreign Patent References

  • 15323 AU 10/12/1988

International Class

A61F 013/02

Abstract

The present invention provides compositions and methods for the transdermal administration of a therapeutically effective amount of a synthetic 19-nor-progesterone (ST-1435) and an estrogen, in combination, together with, optionally, a suitable permeation enhancer.

Other References

  • Knepp et al., "Transdermal Drug Delivery: Problems and Possibilities," CRC Critical Reviews in Therapeutic Drug Carrier System, vol. 4, Issue 1, pp. 13-37 (1987)
  • Pannatier, et al., "The Skin as a Drug Metabolizing Organ," Drug Metabolism Review, vol. 8, No. 2, pp. 319-343 (1978)
  • Suhonen et al., "Endometrial effect of transdermal estradiol and progestin ST-1435 in postmenopausal women", Fertility and Sterility, vol. 57, No. 6, pp. 1211-1215, Jun. 199
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