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High purity beta-carotene

Patent 5310554 Issued on May 10, 1994. Estimated Expiration Date: Icon_subject October 27, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3039877

3492202

Production of glycerol, carotenes and algae meal
Patent #: 4199895
Issued on: 04/29/1980
Inventor: Avron ,   et al.

Extraction process for beta-carotene
Patent #: 4439629
Issued on: 03/27/1984
Inventor: Ruegg

Process for producing a naturally-derived carotene/oil composition by direct extraction from algae
Patent #: 4680314
Issued on: 07/14/1987
Inventor: Nonomura

Naturally-derived carotene/oil composition
Patent #: 4713398
Issued on: 12/15/1987
Inventor: Nonomura

Extraction of anti-mutagenic pigments from algae and vegetables
Patent #: 4851339
Issued on: 07/25/1989
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Recovery of carotenoids
Patent #: 5019668
Issued on: 05/28/1991
Inventor: Keat, et al.

Porous pharmaceutical form and its preparation Patent #: 5206025
Issued on: 04/27/1993
Inventor: Courteille, et al.

Inventor

Assignee

Application

No. 967897 filed on 10/27/1992

US Classes:

424/439, Food or edible as carrier for pharmaceutical424/195.17, EXTRACT OR MATERIAL CONTAINING OR OBTAINED FROM AN ALGA AS ACTIVE INGREDIENT (E.G., CHLORELLA, SEAWEED, LAVER, KELP, ETC.)424/452, With claimed designated perfecting feature in contents (e.g., excipient, lubricant, etc.)424/464, Tablets, lozenges, or pills424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)585/825With fractional or linear desorption, e.g., chromatography, etc.

Examiners

Primary: Page, Thurman K.

Attorney, Agent or Firm

International Classes

A61K 009/16
A61K 009/48
A61K 009/20
A61K 035/78

Abstract

Compositions of high-purity natural beta-carotene and of the 9-cis isomer of beta-carotene are provided, as are methods for the production of these compositions from plant matter, conveniently algae such as Dunaliella species. Typically, the compositions contain at least about 5% 9-cis beta-carotene and less than or equal to 40% of all-trans-beta-carotene, and in some cases may contain 75% 9-cis beta-carotene or higher. The compositions are suitable for administration to humans or other animals, particularly for oral delivery, in a variety of formulations and dosages as pharmaceutical agents or as dietary supplements.

Other References

  • Ben-Amotz et al., "Bioavailability of a Natural Isomer Mixture as Compared with Synthetic all-trans-B-Carotene in Rats and Chicks," J. Nutr. 119(7):1013-1019, 1989
  • Ben-Amotz, "The Wavelength Dependence of Massive Carotene Synthesis in Dunaliella bardawil (Chlorophyceae)," J. Phycol. 25:175-178, 1989
  • Ben-Amotz et al., "Stereoisomers of B-Carotene and Phytoene in the Alga Dunaliella bardawil," Plant Physiol. 86:1286-1291, 1988
  • O'Neil et al., "Comparison of Liquid Chromatographic Methods for Determination of Cis-Trans Isomers of B-Carotene," J. Assoc. Off. Anal. Chem. 74:36-42, 1991
  • Burton, "Antioxidant Action of Carotenoids," J. Nutr. 119(1):109-111, 198
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