U.S. patents available from 1976 to present.
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Red blood cell surrogate

Patent 5306508 Issued on April 26, 1994. Estimated Expiration Date: Icon_subject March 11, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Intravascularly administrable, magnetically responsive nanosphere or nanoparticle, a process for the production thereof, and the use thereof
Patent #: 4501726
Issued on: 02/26/1985
Inventor: Schroder ,   et al.

Drug delivery system
Patent #: 4904479
Issued on: 02/27/1990
Inventor: Illum

Viral decoy vaccine Patent #: 5178882
Issued on: 01/12/1993
Inventor: Kossovsky, et al.

Inventors

Application

No. 029773 filed on 03/11/1993

US Classes:

424/493, Containing polysaccharides (e.g., sugars)424/418, Protein or derivative or polysaccharide or derivative424/490, Coated (e.g., microcapsules)424/491, Containing proteins and derivatives424/494, Cellulose derivatives424/498, Containing waxes, higher fatty acids, higher fatty alcohols, or derivatives thereof424/499, Contains proteins or derivative or polysaccharides or derivative514/814, ANEMIA514/832, BLOOD SUBSTITUTE514/833BLOOD PLASMA EXTENDER

Examiners

Primary: Page, Thurman K.
Assistant: Spear, James M.

Attorney, Agent or Firm

International Class

A61K 009/14

Abstract

A red blood cell surrogate which is composed of a nanocrystalline core particle to which an oxygen carrier such as hemoglobin is bound. An oxygen carrier anchor coating is provided between the nanocrystalline core particle and the oxygen carrier in order to provide binding of the oxygen carrier to the nanocrystalline core particle without denaturing the oxygen carrier or otherwise destroying its oxygen carrying capacity. The nanocrystalline core particle with the oxygen carrier bound thereto is coated with an exterior layer of lipid.

Other References

  • Kossovsky, N. et al.: "Nanocrystalline Epstein-Barr Virus Decoys," Jour. Appl. Biomaterials, vol. 2, 251-259 (1991)
  • Levine, H. and Slade, L.: "Another View of Trehalose for Drying and Stabilizing Biological Materials," BioPharm, (May 1992) pp. 36-40
  • Crowe, J. H. et al.: "Interactions of sugars with membranes," Biochimica et Biophisica Acta, 947 (1988) pp. 367-384
  • Fleminger, G. et al.: "Effect of polyethylene glycol on the non-specific adsorption of proteins to Eupergit C and agarose," Jour. Chromatography, 510 (1990) pp. 271-279
  • Bruin, G. J. M., et al.: "Performance of Carbohydrate-Modified Fused-Silica Capillaries for the Separation of Proteins by Zone Electrophoresis," Jour. Chromatography, 480 (1989) pp. 339-349
  • Hjerten, S.: "Free Zone Electrophoresis," Chromatographic Reviews, 9 (1967) pp. 122-219
  • Hjerten, S.: "High-Performance Electrophoresis Elimination of Electroendosmosis and Solute Adsorption," Jour. Chromatography, 347 (1985) pp. 191-198
  • McCormick, R. M.: "Capillary Zone Electrophoretic Separation of Peptides and Proteins Using Low pH Buffers in Modified Silica Capillaries," Anal. Chem. (1988), 60, pp. 2322-2328
  • Gordon, M. J. et al.: "Protocol for Resolving Protein Mixtures in Capillary Zone Electrophoresis," Anal. Chem. (1991), 63, pp. 69-7
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