Fluid handling in mesoscale analytical devices
Patent 5304487 Issued on April 19, 1994. Estimated Expiration Date: 
May 1, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 1, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3799742 3906929 Liquid transport device and method Electrode-containing device with capillary transport between electrodes Method for preparing single cell suspension Capillary transport device having speed and meniscus control means Capillary flow control Laboratory slide Polysilicon binding assay support and methods Biological diagnostic device and method of use InventorsAssigneeApplicationNo. 877536 filed on 05/01/1992US Classes:435/29, Involving viable micro-organism210/500.26, Glass210/634, Liquid/liquid solvent or colloidal extraction or diffusing or passing through septum selective as to material of a component of liquid; such diffusing or passing being effected by other than only an ion exchange or sorption process216/2, ETCHING OF SEMICONDUCTOR MATERIAL TO PRODUCE AN ARTICLE HAVING A NONELECTRICAL FUNCTION216/56, ETCHING TO PRODUCE POROUS OR PERFORATED ARTICLE422/55, Structured visual or optical indicator, per se422/58, In holder or container having special form422/61, Test package or kit422/101, Including means for separating a constituent; e.g., filter, condenser, extractor, etc.422/947, Using capillary action, including fluid transfer through absorbent matrix [B01L 3/00C6C]435/7.2, Involving a micro-organism or cell membrane bound antigen or cell membrane bound receptor or cell membrane bound antibody or microbial lysate435/7.21, Animal cell436/164, OPTICAL RESULT436/524, Carrier is inorganic436/809Multifield plates or multicontainer arraysExaminersPrimary: Housel, James C.Assistant: Torres, Marcos Attorney, Agent or FirmForeign Patent References
International ClassG01N 031/00AbstractDevices are provided for analyzing a fluid cell containing sample. The devices comprise a solid substrate, microfabricated to define at least one sample inlet port and a mesoscale flow system. The mesoscale flow system includes a sample flow channel, extending from the inlet port, and a cell handling region for treating cells disposed in fluid communication with the flow channel. The devices may further include a structure inducing flow of cells in the sample through the flow system. In one embodiment, the cell-handling region may comprise a cell lysis structure to enable the lysis of cells in the sample, prior to, e.g., the detection of an intracellular component in the cell sample. In another embodiment, the cell handling region may comprise a cell capture region, comprising binding sites which reversibly bind to a specific population of cells in the cell sample, to permit the isolation of the specific cell population from the sample. The devices can be utilized in a wide range of automated sensitive and rapid tests for the analysis of a fluid cell containing sample.Other References
Field of SearchStructured visual or optical indicator, per seIn holder or container having special form Test package or kit Carrier is inorganic OPTICAL RESULT APPARATUS INCLUDED IN PROCESS CLAIM (E.G., PHYSICAL SUPPORT STRUCTURES, ETC.) Multifield plates or multicontainer arrays With treatment or replacement of aspirator element (e.g., cleaning, etc.) BIOSPECIFIC LIGAND BINDING ASSAY Volumetric liquid transfer MAINTAINING BLOOD OR SPERM IN A PHYSIOLOGICALLY ACTIVE STATE OR COMPOSITIONS THEREOF OR THEREFOR OR METHODS OF IN VITRO BLOOD CELL SEPARATION OR TREATMENT Animal cell Expressing recombinant tPA Involving nucleic acid Involving a micro-organism or cell membrane bound antigen or cell membrane bound receptor or cell membrane bound antibody or microbial lysate |
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