Method to reduce particle size growth during lyophilization
Patent 5302401 Issued on April 12, 1994. Estimated Expiration Date: 
December 9, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 9, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesSurface modified drug nanoparticles Patent #: 5145684 InventorsAssigneeApplicationNo. 987879 filed on 12/09/1992US Classes:424/501, Contains solid synthetic resin424/9.4, X-ray contrast imaging agent (e.g., computed tomography, angiography, etc.)424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/499, Contains proteins or derivative or polysaccharides or derivative514/171, With additional active ingredient514/777, Carbohydrate or lignin, or derivative514/788, Nitrogen containing514/951POWDERS, GRANULES OR PARTICLES OF SPECIFIED MESH OR PARTICLE SIZEExaminersPrimary: Page, Thurman K.Assistant: Venkat, Jyothsna Attorney, Agent or FirmForeign Patent References
International ClassA61K 009/51AbstractThis invention discloses a composition comprised of nanoparticles having a surface modifier adsorbed on the surface thereof and a cryoprotectant associated therewith, which cryoprotectant is present in an amount sufficient to form a nanoparticle-cryoprotectant composition. A preferred surface modifier is polyvinylpyrrolidone, and a preferred cryoprotectant is a carbohydrate such as sucrose. This invention further discloses a method of making nanoparticles having a surface modifier adsorbed on the surface and a cryoprotectant associated therewith, comprised of contacting said nanoparticles with the cryoprotectant for a time and under conditions sufficient to form a nanoparticle-cryoprotectant composition.Field of SearchParticulate form (e.g., powders, granules, beads, microcapsules, and pellets)Contains proteins or derivative or polysaccharides or derivative Contains solid synthetic resin With additional active ingredient Carbohydrate or lignin, or derivative Nitrogen containing POWDERS, GRANULES OR PARTICLES OF SPECIFIED MESH OR PARTICLE SIZE | |
