U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Method of treating prostatic adenocarcinoma

Patent 5300294 Issued on April 5, 1994. Estimated Expiration Date: Icon_subject April 5, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-଱-reductase
Patent #: 4882319
Issued on: 11/21/1989
Inventor: Holt, et al.

Steroid 5-alpha-reductase inhibitors
Patent #: 4910226
Issued on: 03/20/1990
Inventor: Holt, et al.

Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase
Patent #: 4937237
Issued on: 06/26/1990
Inventor: Holt, et al.

Phosphonic acid substituted steroids as steroid 5଱-reductase inhibitors
Patent #: 4946834
Issued on: 08/07/1990
Inventor: Holt, et al.

Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5-଱-reductase
Patent #: 4970205
Issued on: 11/13/1990
Inventor: Holt, et al.

Steriod 5-alpha-reductase inhibitors
Patent #: 5017568
Issued on: 05/21/1991
Inventor: Holt, et al.

7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
Patent #: 5032586
Issued on: 07/16/1991
Inventor: Metcalf, et al.

11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-଱-reductase
Patent #: 5041433
Issued on: 08/20/1991
Inventor: Holt, et al.

Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors Patent #: 5137882
Issued on: 08/11/1992
Inventor: Holt, et al.

Inventor

Assignee

Application

No. 544709 filed on 06/27/1990

US Classes:

424/423, Surgical implant or material424/451, Capsules (e.g., of gelatin, of chocolate, etc.)424/456, Gelatin424/464, Tablets, lozenges, or pills514/169, Cyclopentanohydrophenanthrene ring system DOAI514/172, Hetero ring containing514/173, Spiro ring system514/177, Oxygen double bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system514/178, Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system514/182, Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system514/319, The additional ring is one of the cyclos in a polycyclo ring system514/428, Chalcogen bonded indirectly to the five-membered hetero ring by acyclic nonionic bonding514/462, Spiro ring system514/510, Polycyclo ring system514/573Cyclopentyl or cyclopentene (e.g., prostaglandins, etc.)

Examiners

Primary: Page, Thurman K.
Assistant: Azpuru, C.

Attorney, Agent or Firm

Foreign Patent References

  • 0004949B1 EP. 04/13/1978
  • 200859 EP. 11/13/1986
  • 279010 EP. 08/13/1988
  • 0285383A2 EP. 10/13/1988
  • 414490A EP. 02/13/1991
  • 414491A EP. 02/13/1991
  • 9100733 WO. 01/13/1991

International Classes

A61K 009/20
A61K 009/48
A61K 031/56
A61K 031/58

Abstract

Invented is a Method of Treating Prostatic Adenocarcinoma by employing a steroid 5-଱-reductase inhibiting compound or a combination of steroid 5-଱-reductase inhibiting compounds.

Other References

  • "Retardation of Prostate Tumor Progression in the Noble Rat by 4-Methyl-4-Aza-Steroidal Inhibitors of 5 Alpha-Reductase", Kadohama et al; J. Natl. Cancer Inst; 74(2):475-86 1985 ISSN 0027-8874
  • Gormley, The Urologic Clinics of North America vol. 18; No. 1, pp. 93-98 (1991)
  • Sandberg, et al. Progress in Cancer Research Therapy vol. 31; No. 2, pp. 477-489 (1984)
  • Holt et al, J. Med. Chem. vol. 33; No. 3, pp. 937-942 (1990), pp. 943-950
  • Holt et al, Med. Chem. vol. 33; No. 3, pp. 943-950 (1990)
  • Levy et al., J. Steroid Biochem. vol. 34; Nos. 1-6, pp. 571-575 (1989)
  • The Prostate 18:215-227, (1991); Brooks, et al
  • J. Steroid Biochem (24), 1986, 887-86; Cooke, et al
  • Bio Chemistry (28), 1989, Brandt, et al
  • Liang et al., Endocrinology, 117 No. 2, 571-579 (1985)
  • Petrow et al., Novel Approaches to Cancer Chemotherapy, pub: Academic Press, Inc., CH.8.V 269-304 (1984
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