Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation
Patent 5296594 Issued on March 22, 1994. Estimated Expiration Date: 
March 22, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 22, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMethod of producing tumor antibodies Detection of colorectal carcinoma Isolation of unreduced oligosaccharides Oligosaccharides Synthesis of tumor antigenic determinant Disaccharides formed by patterns having a glucosamine and uronic acid structure, preparation thereof and biological applications Synthesis of tumor antigenic determinant 2-(1-oxo-3-thiolanyl)-2-penem antibiotics Oligosaccharides and their biological applications Process for the organic synthesis of oligosaccharides and derivatives thereof InventorsAssigneeApplicationNo. 545999 filed on 06/28/1990US Classes:536/53, Oxygen double bonded and nitrogen bonded directly to the same carbon435/7.23, Tumor cell or cancer cell435/7.9, Assay in which an enzyme present is a label435/188, Stablizing an enzyme by forming a mixture, an adduct or a composition, or formation of an adduct or enzyme conjugate436/543, INVOLVING PRODUCING OR TREATING ANTIGEN OR HAPTEN436/544, Producing labeled antigens530/403, Protein is identified as an antigen, e.g., immunogenic carriers, etc.530/413, Immunological separation or affinity chromatography536/18.2Containing -C(=X)X- wherein the X's are the same or diverse chalcogensExaminersPrimary: Saunders, DavidAttorney, Agent or FirmForeign Patent References
International ClassesC07H 005/06C07K 003/20 G01N 033/531 AbstractThe stereochemistry of sialylation of an acceptor saccharide to obtain an (2-3) or (2-6) linkage is controlled to favor the a anomer by use of an aromatic ester of the sialyl reagent. The resulting intermediate (2-3) and (2-6) sialylated intermediate disaccharide blocks are useful in the synthesis of antigenic substances which can be used to raise antibodies useful in diagnosis and therapy, and can themselves be used as reagents in various applications. The preparation of the tetrasaccharide antigens corresponding to the 19-9 and sialyl-X antigens characteristic of malignant tissue illustrates the application of this method.Other References
Field of SearchTumor cell or cancer cellAssay in which an enzyme present is a label Stablizing an enzyme by forming a mixture, an adduct or a composition, or formation of an adduct or enzyme conjugate Producing labeled antigens Radioactive label Fluorescent label Cancer INVOLVING PRODUCING OR TREATING ANTIGEN OR HAPTEN Protein is identified as an antigen, e.g., immunogenic carriers, etc. Immunological separation or affinity chromatography HAPTEN CONJUGATED WITH PEPTIDE OR PROTEIN Oxygen double bonded and nitrogen bonded directly to the same carbon Containing -C(=X)X- wherein the X's are the same or diverse chalcogens |
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