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Bioactive agents and compositions for materials comprising the bioactive agent and a method for treating materials therewith

Patent 5296464 Issued on March 22, 1994. Estimated Expiration Date: Icon_subject October 21, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Use of lactoferrin for treatment of toxic effects of endotoxins Patent #: 5240909
Issued on: 08/31/1993
Inventor: Nitsche

Inventors

Assignee

Application

No. 780535 filed on 10/21/1991

US Classes:

514/6, Heavy metal containing (e.g., hemoglobin, etc.)424/439, Food or edible as carrier for pharmaceutical424/442, Animal food426/322, Treatment with heavy metal or compound thereof426/335, Biocidal or disinfecting chemical agent426/532, With biocide or biostat435/244, Chemical stimulation of growth or activity by addition of chemical compound which is not an essential growth factor; stimulation of growth by removal of a chemical compound530/400Metal containing, e.g., chromoproteins, ferritin, ferredoxins, etc.

Examiners

Primary: Russel, Jeffrey E.

Attorney, Agent or Firm

Foreign Patent References

  • 130228 EP 01/13/1985

International Classes

A23L 003/346.3
A61K 037/14
C07K 015/22
C12N 001/38

Foreign Application Priority Data

1989-02-25 JP

Abstract

Bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin and having selective biological activities, i.e. growth-inhibitory activity against certain harmful microorganisms on one hand and growth-promoting activity upon certain useful microorganisms on the other hand; as well as compositions, products or materials therefor comprising the bioactive agents consisting of one or more lactoferrin-compounds selected from the group; and a method for treating materials, which are edible for human beings or animals or which are applicable to a portion of body of human beings or animals, with the bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin or the compositions comprising the bioactive agent consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin as an effective component.

Other References

  • "Iron-Binding Proteins in Milk and Resistance to Escherichia coli Infection in Infants" by J. J. Bullen et al, British Medical Journal, Jan. 8, 1972, pp. 69-75, 1972
  • "Comparative Studies on the Chemical and Immunochemical Properties of Human Milk, Human Pancreatic Juice and Bovine Milk Lactoferrin", Chi-Sun Wang et al, Comp. Biochem. Physiol, vol. 78B, No. 3, pp. 575-580, 1984
  • "Comparative Study of the Primary Structures of Sero-, Lacto- and Ovotrans-Ferrin Glycans from Different Species", by G. Spik et al, Biochimie 70 (1988), pp. 1459-1469
  • "Isolation and Characterisation of Lactoferrin Separated from Human Whey by Adsorption Chromatography Using Cibacron Blue F3G-A Linked Affinity Adsorbent", Clinica Chimica Acta, 157 (1986) pp. 89-93, by W. R. Bezwoda et al
  • "Milk Proteins, Chemistry and Molecular Biology", vol. II, 1971, Academic Press, Edited by Hugh A. McKenzie, Chapter 16 on Minor Milk Proteins and Enzymes, pp. 367-375
  • "Zinc and Copper Binding Proteins in Human Milk", The American Journal of Clinical Nutrition 36: Dec. 1982, by Bo Lonnerdal et al, pp. 1170-1176
  • "Lactofferin in Milk from Different Species", Comp. Biochem. Physiol., 1971, vol. 39B, pp. 119-129, by P. L. Masson et al., Pergamon Press/Great Britain
  • Welsh et al., The Journal of Pediatrics, vol. 94 (1979), pp. 1-9
  • Nonnecke et al., Journal of Dairy Science, vol. 67 (1984), pp. 606-613
  • Stephens et al., Immunology, vol. 41 (1980), pp. 597-603
  • Blakeborough et al., Zinc Binding in Cow's Milk and Human Milk, vol. 209, Biochem. J (1983), pp. 505-512, Great Britain
  • Broxmeyer et al., Specificity and Modulation of the Action of Lactoferrin, a Negative Feedback Regulator of Myelopoiesis, Blood, vol. 55, No. 2 (1980), pp. 324-333
  • Davidson et al., Fe-Saturation and Proteolysis of Human Lactoferrin: Effect on Brush-Border Receptor-Mediated Uptake of Fe and Mn, Am. J. Physiol., vol. 257 (1989), G930-4
  • Lonnerdal et al., Manganese Binding Proteins in Human and Cow's Milk The American Journal of Clinical Nutrition, vol. 41 (1985), pp. 550-559, US
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