Method of preparing medical aerosol formulations including drug dissolved in reverse micelles
Patent 5292499 Issued on March 8, 1994. Estimated Expiration Date: 
January 30, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 30, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesDrug-containing chlorofluorocarbon aerosol propellent formulations Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations Patent #: 5230884 InventorsAssigneeApplicationNo. 828195 filed on 01/30/1992US Classes:424/45, Organic pressurized fluid424/43, EFFERVESCENT OR PRESSURIZED FLUID CONTAINING424/450, Liposomes514/937DISPERSION OR EMULSIONExaminersPrimary: Page, Thurman K.Assistant: Bawa, Raj Attorney, Agent or FirmForeign Patent References
International ClassA61K 009/12AbstractThe present invention provides a method for the production of medicinal aerosol compositions which are made up of a homogenous solution of aerosol propellants, a surfactant and a pharmaceutically active compound, where the process comprises purifying the surfactant, removing the water from the surfactant, and dispersing the surfactant in an aerosol propellant with a hydrophilic pharmaceutical composition and a controlled amount of water. The present invention also provides medicinal aerosol compositions produced by this method which are a homogenous solution of the pharmaceutically active compound contained in reverse micelles made up of the surfactant; and methods of using the medicinal aerosols to provide an effective amount of a therapeutic agent.Other References
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