Patent 5290571 Issued on March 1, 1994. Estimated Expiration Date: March 1, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
The present invention is concerned with a whey protein composition comprising a suitable concentration of whey protein concentrate wherein the whey protein concentrate contains proteins which are present in an essentially undenatured state and wherein the biological activity of the whey protein concentrate is dependent on the overall amino acid and small peptides pattern resulting from the contribution of all its protein components and a method of producing said whey protein composition. The invention also relates to several applications of said composition.
Other References
Baricelli, G. C.: De seri facultatibus, et usu, opusculum secundum, Scorriggium, Publ. Naples, Italy, pp. 105-147, 1603
Cantani, A.: Latte e siero di latte in-Materia medica e terapeutica-vol. 1-Vallardi F. Publ., Milano, Italy, p. 385, 1869
Hoffman, K. F.: Zur geschichte der molkenkuren, insbesondere im 17, 18 und 19 Jahrhundert. Med. Monatschr 15: 411-416, 1961
Barness, L. A., et al.: Progress of premature infants fed a formula containing demineralized whey. Pediatrics, Jul. 1963, pp. 52-55
Raiha, N. C. R., et al.: Milk protein quantity and quality in low birth weight infants I. Metabolic responses and effects on growth. Pediatrics 57:659-674, 1976
Rassin D. K. et al.: Milk protein quantity and quality in low birth weight infants. J. Pediat. 90: 356-360, 1977
Berger, H. M., et al: Curd and whey proteins in the nutrition of low birth weight babies. Arch. Dis. in Child. 54: 98-104, 1979
Mietens, C. et al.: Treatment of infantile E. coli gastroenteritis with specific bovine anti-E. coli milk immunoglobulins. Europ. J. Pediatr. 132: 239-252, 1979
Bounous, G. et al: Influence of dietary lactalbumin hydrolysate on the immune system of mice and resistance to Salruonellosis. J. Infect. Dis. 144: 281, 1981
Williamson, J. M. et al: Stimulation of hepatic gluathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxo-L-prolinase substrate. Proc. Natl. Acad. Sci. (USA) 78: 936-939, 1981
Williamson, J. M. et al: Intracellular cysteine delivery system that protects against toxicity by promoting GSH synthesis. Proc. Natl. Acad. 79: 6246-6249, 1982
Bounous, G. et al.: Influence of dietary proteins on the immune system of mice. J. Nutr. 112: 1747-1755, 1982
Birt, D. et al: Nutritional evaluation of three dietary levels of lactalbumin throughout the lifespan of two generations of Syrian hamsters. J. Nutr. 112: 2151-2160, 1982
Birt, D. F., et al.: Survival of hamsters fed graded levels of two protein sources. Lab. Animal Sci. 32: 363-366, 1982
Bounous, G. et al.: Influence of dietary protein type on the immune system of mice. J. Nutr. 113: 1415-1421, 1983
Volz, V. R. et al: Growth and plasma amino acid concentrations in term infants fed either whey-predominant formula or human milk. J. Pediatr. 102: 27-31, 1983
Esterela, J. M. et al: The effect of cysteine and N-acetylcysteine on rat liver glutathione. Biochem. Pharmacol. 32: 3483-3485, 1983
Anderson, M. E. et al: Transport and direct utilization of gamma-glutamylcysteine for glutathione synthesis. Proc. Natl. Acad. Sci. (USA) 80: 707-711, 1983
Puri, R. N. et al: Transport of glutathione as gamma-glutamylcysteinyl-glycylester into liver and kidney. Proc. Natl. Acad. Sci. (USA) 80: 5258-5260, 1983
Janas, L. M. et al: Indices of protein metabolism in term infants fed human milk, whey predominant formula or cow's milk formula. Pediatrics 75: 775-784, 1985
Darling, P. et al: Protein quality and quantity in preterm infants receiving the same energy intake. Am. J. Dis. of Child. 139: 186-190, 1985
Bounous, G. et al: Mechanism of altered ଲ-cell response induced by changes in dietary protein type in mice. J. Nutr. 115: 1409-1417, 1985
Shenai, J. P. et al: Nutritional balance studies in very low birth weight infants: role of whey formula. J. Ped. Gastr. and Nutr. 5: 428-433, 1986
Lauterburg, B. H. et al: Therapeutic doses of acetaminophen stimulate the turnover of cysteine and glutathione in man. J. Hepat. 4: 206-211, 1987
Bounous, G., et al: Dietary whey protein inhibits the development of dimethylhydrazine induced malignancy. Clin. Invest. Med. 11: 213-217, 1988
Tacket, C. O. et al: Protection by milk immunoglobulin concentrate against oral challenge with enterotoxigenic Escherichia Coli. New Engl. J. Med. 318: 1240-1243, 1989
Taylor, Y. C. et al: Elevation of intracellular glutathione levels following depletion and its relationship to protection against radiation and alkylating agents. Pharmacology Ther. 39: 293-299, 1988
White, C. W. et al: Hypoxia increases glutathione redox cycle and protects rat lungs against oxidants. J. Appl. Physiol 65: 2607-2616, 1988
Bounous, G. et al: The immunoenhancing property of dietary whey protein concentrate. Clin. Invest. Med. 121: 271-278, 1988
Bounous, G. et al: Influence of protein type in nutritionally adequate diets on the development of immunity in "Absorption and utilization of amino acids". C.R.C. Press, Ed. M. Friedman, pp. 219-232, 1989
Bounous, G. et al: Immunoenhancing property of dietary whey protein in mice: role of glutathione. Clin. Invest. Med. 12: 154-161, 1989
Papenburg, R. et al: Dietary milk proteins inhibit the development of dimethylhydrazine induced malignancy. In press, Tumor Biology
Schaedler, R. W., et al: Effect of dietary proteins and amino acids on the susceptibility of mice to bacterial infections. J. Exp. Med. 110: 921-934, 1959
Hirayama, T.: An epidemiological study on the effect of diet, especially of milk, on the incidence of stomach cancer. Abstr. 9th Int. Cancer Congress, Tokyo, Japan 713, 1966
Jacquet, J. et al: Nutrition et cancer experimental: cas du lait. C. R. Hebd. Seanc. Acad. de France, 54: 112-120, 1968
I.A.R.C. International microecology group. Dietary fiber, transit-time, fecal bacteria steroids, and colon cancer in two Scandinavian populations. Lancet II, 207-211, 1977
Gridley, D. S. et al: Modification of Herpes 2-transformed cell-induced tumors in mice fed different sources of protein fat and carbohydrate. Cancer Letters 17: 161-173, 1982
Nutter, R. L. et al: Modification of a transplantable colon tumor and immune responses in mice fed different sources of protein, fat and carbohydrate. Cancer Letters 18: 49-62, 1983
Nutter, R. L. et al: BALB/c male mice fed milk or beef protein: Differences in response to 1,2-dimethylhydrazine carcinogenesis. J.N.C.I. 71: 867-874, 1983
Reddy, G. V., et al: Antitumor activity of yogurt components. J. Food Protection 46: 8-11, 1983
Tsuru, S. et al: Inhibition of tumor growth by dairy products. J. Clin. Lab. Immunol. 25: 177-183, 1988
Perdigon, G. et al: Systemic augmentation of the immune response in mice by feeding fermented milks with Lactobacillus casei and Lactobacillus acidophilus. Immunology 63: 17-23, 1988
K. R. Marshall, "Industrial Isolation of Milk Proteins: Whey Proteins," Developments in Dairy Chemistry (P. F. Fox, ed.), Appl. Sci. Publ., N.Y.:339-373(1982) (Exhibit A)
Rodney J. Brown, "Milk Coagulation and Protein Determination," Fundamentals of Dairy Chemistry (N. P. Wong, ed.), Van Nostrand Reynolds Co., N.Y.:583-607,(1988) (Exhibit B)
R. McL. Whitney, "Proteins of Milk," Fundamentals of Dairy Chemistry (N. P. Wong, ed.), Van Nostrand Reynolds Co., NY: 81-169 (1988) (Exhibit C
March 1, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
