Capture sandwich hybridization method and composition
Patent 5288609 Issued on February 22, 1994. Estimated Expiration Date: 
October 30, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
October 30, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesDetection of microbial nucleic acids by a one-step sandwich hybridization test Patent #: 4486539 InventorsAssigneeApplicationNo. 968706 filed on 10/30/1992US Classes:435/6, Involving nucleic acid435/803, PHYSICAL RECOVERY METHODS (E.G., CHROMATOGRAPHY, GRINDING)436/520, Red blood cell436/527, Glass or silica436/533Carrier is water suspendible particles (e.g., latex, etc.)ExaminersPrimary: Rollins, John W.Attorney, Agent or FirmForeign Patent References
International ClassesC12Q 001/68G01N 033/555 G01N 033/552 G01N 033/546 AbstractThis invention provides methods and compositions for the detection of a target genetic material having a desired base sequence or gene. Also disclosed are methods and compositions for the detection of mutants. The methods and compositions are based in part upon techniques which utilize two labeled single-stranded polynucleotide segments which are complementary to different portions of the genetic material. The methods and compositions of this invention result in the formation of a double hybrid and/or multihybrid, and can furthermore be employed in an attached system, i.e., a matrix-bound entity capable of binding to a polynucleotide probe entity.Other References
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