NMDA-blocking pharmaceutical compositions
Patent 5284867 Issued on February 8, 1994. Estimated Expiration Date: 
April 8, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 8, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesHexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents Novel tetrahydrocannabinol type compounds Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents (3S-4S)-7-hydroxy-Ɗ6 -tetrahydrocannabinols Patent #: 4876276 InventorsAssigneeApplicationNo. 865088 filed on 04/08/1992US Classes:514/454Tricyclo ring system having the hetero ring as one of the cyclosExaminersPrimary: Chan, NickyAttorney, Agent or FirmForeign Patent References
International ClassA61K 031/35Foreign Application Priority Data1989-11-07 ILAbstractThe use of a compound of the formula: ##STR1## having the (3S,4S) configuration, and which is essentially free of the (3R,4R) enantiomer, wherein A--B designates a 1(2) or a 6(1) double bond, R designates --CH3 or --CH2 OH, R1 designates a hydrogen atom or a lower acyl group, and R2 designates (A) a straight-chained or branched C6-12 alkyl radical; or (B) a group --O--R3, in which R3 is a straight-chained or branched C5-9 alkyl radical or a straight-chained or branched alkyl radical substituted at the terminal carbon atom by a phenyl group in the manufacture of a medicament for reducing or preventing glutamate neurotoxicity. Some of the above compounds are novel, and their preparation is described. Also described is a method of treating acute injuries to the central nervous system associated with excitatory amino acid neurotoxicity, a method of treating chronic degenerative disease associated with gradual selective neuronal loss and a method of treating poisonings affecting the central nervous system by administering a pharmaceutical composition containing the above compound.Other References
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