Patent 5284663 Issued on February 8, 1994. Estimated Expiration Date: July 23, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)264/4.1, Liquid encapsulation utilizing an emulsion or dispersion to form a solid-walled microcapsule (includes liposome)424/490, Coated (e.g., microcapsules)424/497Containing solid synthetic polymers
An artificial blood substitute comprising Lewis acid--Lewis base salt film microcapsule having a perfluorocarbon encapsulated therein. The Lewis base may be a polyoxyalkylene adduct of an amine and the Lewis acid may be a polyoxyalkylene derivative of a polymeric acid.
Other References
"Controlled Release By Using Poly Methacrylic Hydrogels" Journal of Controlled Release, 16, Peppas et al. pp. 203-214, 1991
"Oil Spill Identification with Microencapsulated Compounds Suitable for Electron Capture" Environmental Science & Technology, 7, No. 2, Mitchell et al. pp. 121-124, 1973
"Perfluorocarbon Blood Substitutes" CRS Critical Reviews in Oncology Hematology, 6, issue 4, Biro et al., pp. 311-374, 1987
Synthetic Blood & Medical Technologies Inc. pp. 12, 28, 30, 32, 34, 38, 40 and 4