Fused pyrazine derivatives
Patent 5283244 Issued on February 1, 1994. Estimated Expiration Date: 
May 3, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 3, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References(1H-azol-1-ylmethyl)substituted quinoxaline derivatives Patent #: 5028606 InventorsAssigneeApplicationNo. 050225 filed on 05/03/1993US Classes:514/249, 1,4-diazine as one of the cyclos514/234.5, Plural ring nitrogens in the bicyclo ring system514/250, At least three rings in the polycyclo ring system544/116, The diazine ring is one of the cyclos in a bicyclo ring system544/119, Acyclic nitrogen containing544/350, Three or more ring hetero atoms in the bicyclo ring system544/354Chalcogen bonded directly to diazine ring carbonExaminersPrimary: Ramsuer, Robert W.Attorney, Agent or FirmInternational ClassesA61K 031/495A61K 031/535 C07D 403/02 C07D 413/14 Foreign Application Priority Data1990-11-06 JPAbstractThe present invention is a pyrazine derivative which has glutamate receptor antagonizing activity, represented by formula: ##STR1## wherein Z represents C or N, provided that two Zs are not N atoms at the same time; R1 represents: ##STR2## wherein ##STR3## represents ##STR4## R6 represents H or alkyl, and R7 and R8 represent each H, alkyl, nitro or phenyl, or alternatively R7 and R8 are combined together to represent butadienylene or 1,4-butylene; R2 and R3 represent each H, F, cyano, acyl, nitro, alkyl, morpholino or one of said species of R1 ; R4 and R5 represent each H, hydroxyl, alkyl, cycloalkyl, heterocycle, phenyl, or Y-substituted alkyl; Y represents hydroxyl, acyloxy, F-substituted methyl, cycloalkyl, tetrahydrofuryl, carboxyl, alkoxycarbonyl or ##STR5## R9 and R10 represent each H or alkyl, or alternatively R9 and R10 are combined together to represent a 5- or 6-membered cyclic group which may contain oxygen atom(s).Field of SearchThe diazine ring is one of the cyclos in a bicyclo ring systemAcyclic nitrogen containing Three or more ring hetero atoms in the bicyclo ring system Chalcogen bonded directly to diazine ring carbon Plural ring nitrogens in the bicyclo ring system 1,4-diazine as one of the cyclos At least three rings in the polycyclo ring system |
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