Process for producing optically active -substituted organic acid and microorganism and enzyme used therefor
Patent 5283193 Issued on February 1, 1994. Estimated Expiration Date: 
November 27, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 27, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesProcess of preparing L and D -amino acids by enzyme treatment of DL--amino acid amide Process for preparing L--methylphenyl alanines Optically active substituted butyramide, and process for the optical separation of substituted butyramide Patent #: 4812403 InventorsAssigneeApplicationNo. 799879 filed on 11/27/1991US Classes:435/280Resolution of optical isomers or purification of organic compounds or composition containing sameExaminersPrimary: Lee, Lester L.Attorney, Agent or FirmForeign Patent References
International ClassC12P 007/40Foreign Application Priority Data1988-06-27 JPAbstractA process for producing an optically active -substituted organic acid represented by formula (II), comprising the steps of (a) treating a racemic substituted nitrile or amide represented by formula (I) with a microorganism selected from the group consisting of the microorganisms of genuses Alcaligenes, Pseudomonas, Rhodopseudomonas, Corynebacterium, Acinetobacter, Bacillus, Mycobacterium, Rhodococcus and Candida, or preparations thereof; and (b) recovering the resulting optically active u-substituted organic acid represented by formula (II): ##STR1## wherein R1 and R2 each represent a halogen atom, a hydroxyl group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aryloxy group or a substituted or unsubstituted heterocyclic group with the proviso that R1 and R2 are different from each other; and X represents a nitrile group or an amido group, ##STR2## wherein R1 and R2 are as defined above.Other References
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