Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
Patent 5283065 Issued on February 1, 1994. Estimated Expiration Date: 
March 23, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 23, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2687367 2887436 2953497 3080294 3115441 3344029 3865935 Sustained release tablet formulations Sustained release indomethacin Orally administrable pharmaceutical composition InventorsAssigneeApplicationNo. 859617 filed on 03/23/1992US Classes:424/467, Printed, embossed, grooved, or perforated424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)424/468, Sustained or differential release type424/469, Discrete particles in supporting matrix424/472, Layered unitary dosage forms424/474, Coated pills or tablets424/480, Cellulose or derivative424/482, Containing solid synthetic polymers424/484, Matrices424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/494, Cellulose derivatives424/497Containing solid synthetic polymersExaminersPrimary: Page, Thurman K.Assistant: Spear, James M. Attorney, Agent or FirmForeign Patent References
International ClassesA61K 009/14A61K 009/44 A61K 009/52 AbstractA controlled release pharmaceutical composition in oral dosage unit form comprising a tablet comprising a therapeutically effective number of active spherical granules comprising an effective amount of active medicament, a pharmaceutically acceptable normally solid diluent adapted to form a diffusable matrix for the active medicament and an optional pharmaceutically acceptable excipient; and a number of compressible spherical granules comprising a mono- or di-saccharide, an optional pharmaceutically acceptable normally solid diluent adapted to form a diffusable matrix, an optional active medicament and/or an optional pharmaceutically acceptable excipient wherein the average compressive yield of the compressible spherical granules is less than the average compressive yield of the active spherical granules is provided. A method for the preparation and for the administration of the above defined composition is provided as well.Field of SearchParticulate form (e.g., powders, granules, beads, microcapsules, and pellets)Sustained or differential release type Discrete particles in supporting matrix Where particles are granulated Containing solid synthetic polymers Contains proteins or derivative or polysaccharides or derivative Coated (e.g., microcapsules) Cellulose derivatives | |
