Fibrinogen receptor antagonists for inhibiting aggregation of blood platelets
Patent 5281585 Issued on January 25, 1994. Estimated Expiration Date: 
November 6, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 6, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesCompositions containing new indole derivatives and their use in pharmacology Substituted amides and sulfonamides containing a heterocyclic group having antiinflammatory activity 4-Phenoxymethyl-piperidines Phenylsulphonamide derivatives, anti-arrhythymic compositions and use Glutaramide diuretic agents Anti-thrombotic peptide and pseudopeptide derivatives Patent #: 5064814 Inventors
AssigneeApplicationNo. 972668 filed on 11/06/1992US Classes:514/79, Nitrogen containing hetero ring514/80, Polycylo ring system having a ring nitrogen in the system514/86, Nitrogen atoms occupy 1 and 3- positions514/89, Hetero ring is six-membered and includes only one ring nitrogen514/90, Chalcogen in the six-membered hetero ring514/91, Hetero ring is five-membered514/92, Two or more hetero atoms in the five-membered ring514/211.08, Plural ring nitrogens in the seven-membered hetero ring514/211.15, Additional nitrogen containing hetero ring attached directly or indirectly to the seven-membered hetero ring by nonionic bonding514/212.08, Additional hetero ring attached directly or indirectly by nonionic bonding to the seven-membered hetero ring514/218, Hetero ring is seven-membered consisting of two nitrogens and five carbon atoms514/222.2, Hetero ring is six-membered and includes at least nitrogen and sulfur as ring members514/222.5, Three or more ring hetero atoms in the six-membered hetero ring514/253.01, The additional hetero ring is six-membered consisting of one nitrogen and five carbon atoms514/256, 1,3-diazines (e.g., pyrimidines, etc.)514/299, Bicyclo ring system having the six-membered hetero ring as one of the cyclos514/316, Plural piperidine rings514/318, The additional ring is a six-membered hetero ring consisting of one nitrogen and five carbon atoms514/326, The additional ring is a hetero ring514/331, Nitrogen attached indirectly to the piperidine ring by nonionic bonding514/460, Chalcogen bonded directly to ring carbon of the hetero ring514/463, Plural ring oxygens in the hetero ring514/492, Heavy metal containing DOAI514/524, The cyano is bonded directly to a benzene ring544/3, Six-membered hetero ring consists of sulfur, nitrogen, and carbon544/7, Plural nitrogens in the six-membered hetero ring (e.g., thiatriazines, etc.)544/316, Nitrogen attached directly or indirectly to the diazine ring by nonionic bonding544/360, Six-membered ring consisting of one nitrogen and five carbons (e.g., pyridine, etc.)546/22, Phosphorus attached indirectly to the six-membered hetero ring by nonionic bonding546/125, Additional hetero ring containing546/183, Chalcogen bonded directly to ring carbon of the bicyclo ring system546/187, Additional hetero ring containing546/188, Chalcogen attached directly to a ring carbon of a piperidine ring by nonionic bonding546/193, Pyridine ring or partially hydrogenated pyridine ring546/201, Bicyclo ring system which is indole (including hydrogenated)546/207, The additional ring is a hetero ring546/208, Ring nitrogen in the additional hetero ring546/210, Plural ring nitrogens in the additional hetero ring546/212, The additional hetero ring consists of one sulfur and four carbons546/233, Acyclic nitrogen bonded directly to a -C(=X)- group, wherein X is chalcogen546/300Nitrogen attached indirectly to the six-membered hetero ring by nonionic bondingExaminersPrimary: Cintins, Marianne M.Assistant: Hydorn, Michael B. Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/16A61K 031/445 A61K 031/395 C07D 417/06 C07D 401/06 AbstractFibrinogen receptor antagonists of the formula: ##STR1## are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.Field of SearchChalcogen attached directly to a ring carbon of a piperidine ring by nonionic bondingPhosphorus attached indirectly to the six-membered hetero ring by nonionic bonding Additional hetero ring containing Chalcogen bonded directly to ring carbon of the bicyclo ring system Additional hetero ring containing Pyridine ring or partially hydrogenated pyridine ring Bicyclo ring system which is indole (including hydrogenated) Ring nitrogen in the additional hetero ring Plural ring nitrogens in the additional hetero ring Nitrogen attached indirectly to the six-membered hetero ring by nonionic bonding The additional hetero ring consists of one sulfur and four carbons Acyclic nitrogen bonded directly to a -C(=X)- group, wherein X is chalcogen The additional ring is a hetero ring Six-membered hetero ring consists of sulfur, nitrogen, and carbon Nitrogen attached directly or indirectly to the diazine ring by nonionic bonding Six-membered ring consisting of one nitrogen and five carbons (e.g., pyridine, etc.) Plural nitrogens in the six-membered hetero ring (e.g., thiatriazines, etc.) Additional hetero ring containing Plural nitrogens in the hetero ring Nitrogen or additional chalcogen attached directly to the hetero ring by nonionic bonding Plural nitrogens in the hetero ring Nitrogen containing hetero ring Polycylo ring system having a ring nitrogen in the system Nitrogen atoms occupy 1 and 3- positions Hetero ring is six-membered and includes only one ring nitrogen Chalcogen in the six-membered hetero ring Hetero ring is five-membered Two or more hetero atoms in the five-membered ring Hetero ring is seven-membered consisting of two nitrogens and five carbon atoms Hetero ring is six-membered and includes at least nitrogen and sulfur as ring members Three or more ring hetero atoms in the six-membered hetero ring Bicyclo ring system having the six-membered hetero ring as one of the cyclos Plural piperidine rings The additional ring is a six-membered hetero ring consisting of one nitrogen and five carbon atoms The additional ring is a hetero ring Nitrogen attached indirectly to the piperidine ring by nonionic bonding |
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