Device for iontophoretic non-invasive sampling or delivery of substances

Patent 5279543 Issued on January 18, 1994. Estimated Expiration Date:

April 30, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

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Inventors

Assignee

The Regents of the University of California

Application

No. 879060 filed on 04/30/1992

US Classes:

604/20, Infrared, visible light, ultraviolet, X-ray or electrical energy applied to body (e.g., iontophoresis, etc.)600/395Electrode composition

Examiners

Primary: Howell, Kyle L.
Assistant: Lacyk, John P.

Attorney, Agent or Firm

Phillips, Moore, Lempio & Finley

Foreign Patent References

A7769187 AU. 03/20/1988
120689 EP. 10/20/1984
230749 EP. 05/20/1987
230153 EP. 08/20/1987
240593 EP. 10/20/1987
252732 EP. 01/20/1988
254965 EP. 02/20/1988
267293 EP. 05/20/1988
293893 EP. 07/20/1988
278473 EP. 08/20/1988
278474 EP. 08/20/1988
282982 EP. 09/20/1988
322098 EP. 06/20/1989
8607269 WO. 12/20/1986
8800846 WO. 11/20/1988
2116850 GB. 10/20/1983

International Class

A61N 001/30

Abstract

The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises:(a) a positive electrode;(b) a negative electrode, and(c) electrical insulation between subpart (a) and (b), wherein the positive electrode, and the negative electrode, and electrical insulation are positioned on the same side of the membrane sample.The present invention also relates to a device for the removal of or delivery of ionized substances to a mammal through intact skin or mucosal membrane without mechanical penetration, which device comprises: (a) a positive electrode, (b) a negative electrode, and (c) an electrically insulating material between subpart (a) and (b), wherein the positive electrode, negative electrode and insulating material are physically positioned so that each present a common surface of the device for contact with the same surface of the skin or mucosal membrane of the mammal.The present invention also relates to the use of iontophoresis to determine the level of a charged molecule in a living mammal, and with the use of a feedback mechanism, administer appropriate levels of therapeutic substances.

Other References

J. S. Schultz, "Medical Applications of Fiberoptic Sensors," Medical Instrumentation, vol. 19, #4, (Jul.-Aug., 1985), pp. 158-163
A. P. F. Turner et al., "Commerical Perspectives for Diagnostics Using Biosensors Technologies," ABL, pp. 10-18, published Nov. 1988
W. Schramm, et al., "The Commercialization of Biosensors," MD & DI, pp. 52-57, published in Nov. 1987
A. P. F. Turner, "Diabetes Mellitus, Biosensors for Research and Management," Biosensors, vol. 1, pp. 85-115, published by Elsevier, Ltd., London, U.K
F. B. Benjamin et al. (1954) "Sodium-Potassium Ratio in Human Skin as Obtained by Reverse Iontophoresis," Journal of Applied Physiology, vol. 6, pp. 401-40