Therapeutic compositions with controlled release of medicaments supported on crosslinked polymers and coated with polymer films, and their preparation process
Patent 5275824 Issued on January 4, 1994. Estimated Expiration Date: 
January 4, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 4, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesDrug delivery system Patent #: 4973469 InventorsAssigneeApplicationNo. 620651 filed on 12/03/1990US Classes:424/490, Coated (e.g., microcapsules)424/469, Discrete particles in supporting matrix424/486, Synthetic polymer424/487, Acrylic acid and derivatives424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/497, Containing solid synthetic polymers514/58Dextrin or derivativeExaminersPrimary: Page, Thurman K.Assistant: Benston, William E. Jr. International ClassA61K 009/16Foreign Application Priority Data1990-03-06 ITAbstractThe described therapeutic compositions with controlled release of medicaments comprise a medicament loaded onto particles of a crosslinked non-ionic polymer insoluble but swellable in water, using either swelling with solutions of the medicament or high-energy co-grinding methods. The medicament-loaded particles are coated with a polymers film able to control medicament release, to obtain a prolonged release of the medicament (even exceeding 24 hours) while maintaining high bioavailability. | |
