Stable suspension formulations of bioerodible polymer matrix microparticles incorporating drug loaded ion exchange resin particles
January 4, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesControlled release formulations and method of treatment Device for pH independent release of drugs through the Donnan-like influence of charged insoluble resins Device for the controlled release of drugs with Donnan-like modulation by charged insoluble resins Coatable ion exchange resins Sustained release, comfort formulation for glaucoma therapy Controlled release powder and process for its preparation Muco-bioadhesive composition Vapor deposition patterning method Bioadhesive compositions and methods of treatment therewith Sustained release drug-resin complexes InventorApplicationNo. 634500 filed on 12/27/1990US Classes:424/426, Errodable, resorbable, or dissolving424/428, Bioerrodable, resorbable, or dissolving424/433, Depot, pellet, matrix, or suppository424/434, Mucosal (e.g., nasal, etc.)424/435, Mouth424/436, Anal, rectal (e.g., suppositories, etc.)424/486, Synthetic polymer424/497, Containing solid synthetic polymers427/2.12, For contacting living body or transfusing bodily fluid (e.g., endoscope, electrode, thermometer, probe)427/2.21, Retarded or controlled-release layer produced (e.g., enteric)427/212, PARTICLES, FLAKES, OR GRANULES COATED OR ENCAPSULATED514/772.1, Aftertreated solid synthetic organic polymer (e.g., grafting, blocking, etc.)514/772.5, Heterocyclic monomer514/772.6, Carboxylic acid containing monomer514/912, OPHTHALMIC514/913, Glaucoma514/914, Inflammation514/952WettableExaminersPrimary: Webman, Edward J.Attorney, Agent or FirmInternational ClassesA61K 009/16A61K 009/58 A61K 009/10 AbstractSustained release pharmaceutical compound delivery compositions and methods for their production are disclosed wherein ion exchange resin particles are loaded with releasably bound pharmaceutical compounds prior to incorporation in an erodible polymeric matrix to form microparticulates. The microparticulates are suspended in a fluid medium where the encapsulating polymeric matrix shields the drug loaded ion exchange resin from solvent interaction. Administration to a target tissue site initiations erosion of the polymer matrix and release of the loaded pharmaceutical compound. | |
