Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals
Patent 5273993 Issued on December 28, 1993. Estimated Expiration Date: 
November 19, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 19, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2839562 3082238 3661830 Phenyl-benzoic acid derivatives Aliphatic sulfamates Process for preparation of aliphatic primary sulfamates Inhibition of male fertility with aliphatic sulfamates Certain herbicidal sulfonates and sulfamates Anticonvulsant sulfamate derivatives Chlorosulfate and azidosulfate esters of tetrahydro-2H-pyran-2-yl-methanol Inventors
ApplicationNo. 965140 filed on 11/19/1992US Classes:514/400, At imidazole ring carbon514/309, Chalcogen attached directly to the six-membered hetero ring by nonionic bonding514/311, Quinolines (including hydrogenated)514/312, Chalcogen attached directly to the six-membered hetero ring by nonionic bonding514/347, Chalcogen bonded directly to chalcogen514/348, Chalcogens bonded directly to at least two ring carbons of the six-membered hetero ring514/362, 1,2,5-thiadiazoles (including hydrogenated)514/369, Chalcogen bonded directly to ring carbon of the thiazole ring514/398, Chalcogen or nitrogen bonded directly to the imidazole ring by nonionic bonding514/415, The bicyclo ring system consists of the five-membered hetero ring and a benzene ring (e.g., indole, etc.)514/418, Chalcogen bonded directly to ring carbon of the five-membered hetero ring514/445, Chalcogen bonded directly to ring carbon of the hetero ring514/457, Coumarins (including hydrogenated)514/473, Chalcogen bonded directly to the hetero ring548/335.5, Nitrogen attached indirectly to the diazole ring by acyclic nonionic bonding558/48Nitrogen attached directly or indirectly to the sulfonate group by acyclic nonionic bondingExaminersPrimary: Higel, Floyd D.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/415C07D 233/54 AbstractMethods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula:(HO)p--A--[--OS(O)2 NR1 R2 ]zwherein A encompasses a wide range of values including but not limited to aryl, loweralkyl, cycloalkyl, and carbohydrates including sucrose and fructose; p is equal to the number of unreacted hydroxy groups contained on the molecule and may be zero; z is the number of --OS(O)2 NR1 R2 groups and is always at least one; R1 and R2 are selected from hydrogen, loweralkyl, carboxy and the like; a novel process for preparing the compounds is provided wherein an appropriate sulfamic acid aryl ester is reacted with a hydroxy substituted A radical which may or may not contain thereon protected carboxyl, amino or hydroxy substituents, in an aprotic solvent containing a tertiary amine base. Pharmaceutical compositions for the treatment of chronic arthritis and osteoporosis are also provided.Other References
Field of SearchNitrogen attached indirectly to the diazole ring by acyclic nonionic bondingNitrogen attached directly or indirectly to the sulfonate group by acyclic nonionic bonding Chalcogen attached directly to the six-membered hetero ring by nonionic bonding Quinolines (including hydrogenated) Chalcogen attached directly to the six-membered hetero ring by nonionic bonding Chalcogen bonded directly to chalcogen Chalcogens bonded directly to at least two ring carbons of the six-membered hetero ring The bicyclo ring system consists of the five-membered hetero ring and a benzene ring (e.g., indole, etc.) Chalcogen bonded directly to ring carbon of the five-membered hetero ring 1,2,5-thiadiazoles (including hydrogenated) Chalcogen bonded directly to ring carbon of the thiazole ring Chalcogen or nitrogen bonded directly to the imidazole ring by nonionic bonding Chalcogen bonded directly to ring carbon of the hetero ring Coumarins (including hydrogenated) Chalcogen bonded directly to the hetero ring Additional hetero ring Benzo fused at 4,5-positions of the diazole ring At imidazole ring carbon |
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