Heterocyclic amines having central nervous system activity
Patent 5273975 Issued on December 28, 1993. Estimated Expiration Date: 
December 6, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 6, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole Benzoquinolizines as 2 -adrenoceptor antagonists Di/tetra-hydroquinolines 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity 1,3,4,5-tetrahydrobenz(c,d)indoles Fused heteroalkylene quinolinamines Patent #: 5112830 InventorsAssigneeApplicationNo. 778204 filed on 12/06/1991US Classes:514/233.2, Ring nitrogen shared by two of the cyclos514/253.03, Tricyclo ring system having the additional six-membered nitrogen hetero ring as one of the cyclos514/291, Plural hetero atoms in the tricyclo ring system514/292, Plural ring nitrogens in the tricyclo ring system514/293, Three or more hetero atoms in the tricyclo ring system514/294, Ring nitrogen is shared by two of the cyclos544/126, The additional six-membered hetero ring is one of the cyclos in a tricyclo ring system544/361, The additional six-membered hetero ring is one of the cyclos in a polycyclo ring system546/80, Plural ring hetero atoms in the tricyclo ring system546/82, Three or more ring hetero atoms in the tricyclo ring system546/83, At least one of the ring hetero atoms is chalcogen546/84, One of the cyclos is five-membered546/89, Ring oxygen in the tricyclo ring system546/94Ring nitrogen is shared by two of the cyclosExaminersPrimary: Shah, Mukund J.Assistant: Grumbling, Matthew V. Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/495A61K 031/50 C07D 513/02 C07D 471/06 AbstractTricyclic nitrogen containing compounds, having central nervous system activity of the following structural formula: ##STR1## and pharmaceutically acceptable salts thereof wherein R1, R2, and R3 are independently hydrogen, C1-6 alkyl, alkenyl, or alkynyl, C3-10 cycloalkyl, or R1 and R2 are joined to form a C3-7 cyclic amine which can contain additional heteroatoms; X is hydrogen, C1-6 alkyl halogen, hydroxy, alkoxy, cyano, carboxamide, carboxyl, or carboalkoxyl; A is SO2, N, CH, CH2, CHCH3, C=O, C=S, C-SCH3, C=NH, C-NH2, C-NHCH3, C--NHCOOCH3, or C--NHCN. B is CH2, CH, C=O, N, NH or N--CH3 ; n is 0 or 1; and D is CH, CH2, C=O, O, N, NH or N--CH3. These new compounds are suitable for treating schizophrenia, Parkinson's disease, anxiety, depression or as compounds for lowering blood pressure in animal or human hosts.Other References
Field of SearchThree or more ring hetero atoms in the tricyclo ring systemAt least one of the ring hetero atoms is chalcogen One of the cyclos is five-membered Ring oxygen in the tricyclo ring system Ring nitrogen is shared by two of the cyclos Plural ring hetero atoms in the tricyclo ring system The additional six-membered hetero ring is one of the cyclos in a tricyclo ring system The additional six-membered hetero ring is one of the cyclos in a polycyclo ring system Plural hetero atoms in the tricyclo ring system Plural ring nitrogens in the tricyclo ring system Three or more hetero atoms in the tricyclo ring system Ring nitrogen is shared by two of the cyclos Ring nitrogen shared by two of the cyclos |
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