Controlled release oxycodone compositions
Patent 5266331 Issued on November 30, 1993. Estimated Expiration Date: 
November 27, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 27, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesControlled release bases for pharmaceuticals Controlled release hydromorphone composition Patent #: 4990341 InventorsAssigneeApplicationNo. 800549 filed on 11/27/1991US Classes:424/468, Sustained or differential release type424/469, Discrete particles in supporting matrix424/470, Where particles are granulated424/486, Synthetic polymer424/487, Acrylic acid and derivatives424/488, Polysaccharides (e.g., cellulose, etc.)424/494, Cellulose derivatives424/495, Ethyl cellulose424/496, Containing natural gums/resins424/497, Containing solid synthetic polymers424/498, Containing waxes, higher fatty acids, higher fatty alcohols, or derivatives thereof424/501, Contains solid synthetic resin424/502Contains waxes, higher fatty acids, higher fatty alcoholsExaminersPrimary: Page, Thurman K.Assistant: Spear, James M. Attorney, Agent or FirmInternational ClassesA61K 009/22A61K 009/26 AbstractA solid controlled release, oral dosage form, the dosage form comprising a therapeutically effective amount of oxycodone or a salt thereof in a matrix wherein the dissolution rate in vitro of the dosage form, when measured by the USP Paddle Method of 100 rpm in 900 ml aqueous buffer (pH between 1.6 and 7.2) at 37° C. is between 12.5% and 42.5% (by weight) oxycodone released after 1 hour, between 25% and 55% (by weight) oxycodone released after 2 hours, between 45% and 75% (by weight) oxycodone released after 4 hours and between 55% and 85% (by weight) oxycodone released after 6 hours, the in vitro release rate being independent of pH between pH 1.6 and 7.2 and chosen such that the peak plasma level of oxycodone obtained in vivo occurs between 2 and 4 hours after administration of the dosage form.Field of SearchTablets, lozenges, or pillsWith claimed perfecting feature in contents (e.g., excipient, lubricant, etc.) Sustained or differential release type Discrete particles in supporting matrix Where particles are granulated Synthetic polymer Acrylic acid and derivatives Polysaccharides (e.g., cellulose, etc.) Cellulose derivatives Containing natural gums/resins Containing solid synthetic polymers Containing waxes, higher fatty acids, higher fatty alcohols, or derivatives thereof | |
