Reversible gelation compositions and methods of use
October 12, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesSustained release ophthalmic drug dosage Sustained release ophthalmic drug dosage Ophthalmic drug delivery system utilizing thermosetting gels Drug delivery system utilizing thermosetting gels Topical drug delivery system utilizing thermosetting gels Bioadhesive compositions and methods of treatment therewith Opthalmic use of quinolone antibiotics Sustained release, comfort formulation for glaucoma therapy Patent #: 4911920 InventorsApplicationNo. 539061 filed on 06/15/1990US Classes:424/78.04, Ophthalmic preparation424/9.1, IN VIVO DIAGNOSIS OR IN VIVO TESTING424/422, Implant or insert424/427, Ocular424/428, Bioerrodable, resorbable, or dissolving514/912, OPHTHALMIC514/913, Glaucoma514/914, Inflammation514/915Wetting agentExaminersPrimary: Page, Thurman K.Assistant: Azpuru, Carlos Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/19A61K 031/745 A61K 047/38 A01N 025/04 AbstractReversibly gelling aqueous compositions are disclosed which undergo significant changes in viscosity in response to substantially simultaneous changes in both temperature and pH. The compositions are formed of relatively low concentrations of a stable combination of at least one pH-sensitive reversibly gelling polymer and at least one temperature-sensitive reversibly gelling polymer. The compositions can be formulated to exhibit a sol-gel transition over a wide range of conditions and viscosities and may be modified to incorporate a pharmaceutical compound for utilization as droppable or injectable drug delivery systems which will gel following administration to a physiological system for the sustained delivery of such pharmaceutical compounds. | |
