U.S. patents available from 1976 to present.
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Nucleophilic polysubstituted aryl acridinium esters and uses thereof

Patent 5241070 Issued on August 31, 1993. Estimated Expiration Date: Icon_subject April 17, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3352791

3689391

Polysubstituted aryl acridinium esters
Patent #: 4745181
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Inventor: Law ,   et al.

Polysubstituted aryl acridinium esters
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Inventor: Law, et al.

Process for forming liposomes
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Issued on: 06/12/1990
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Chemiluminescent acridinium labelling compounds
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Inventor: Campbell, et al.

Proteted chemiluminescent labels
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Method of detecting a substance using enzymatically-induced decomposition of dioxetanes
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Issued on: 12/18/1990
Inventor: Bronstein

Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
Patent #: 5004565
Issued on: 04/02/1991
Inventor: Schaap

Process for stabilizing liposomes
Patent #: 5094785
Issued on: 03/10/1992
Inventor: Law, et al.

More ...

Inventor

Assignee

Application

No. 871601 filed on 04/17/1992

US Classes:

546/107, Plural nitrogens, other than as nitro or nitroso, attached directly to the carbocyclic rings of the acridine ring system (e.g., 3,6-diaminoacridines, etc.)436/172, With fluorescence or luminescence534/751, Hetero ring containing534/798, Plural carbocyclic rings bonded directly to the azo group540/2, Cyclopentanohydrophenanthrene ring system containing540/201, Heavy metal containing544/258, Nitrogen bonded directly to the pteridine ring system544/261, Pteroyl per se or having -C(=X)-, wherein X is chalcogen, bonded directly to acyclic nitrogen of otherwise unsubstituted pteroyl546/23, Polycyclo ring system having the six-membered hetero ring as one of the cyclos546/44, One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)546/102, Acridines (including hydrogenated)546/104, Nitrogen, other than as nitro or nitroso, attached directly or indirectly to the acridine ring system by nonionic bonding560/147Sulfur in acid moiety

Examiners

Primary: Daus, Donald G.

Attorney, Agent or Firm

Foreign Patent References

  • 02165553 EP 04/13/1987
  • 0324202 EP 07/13/1989
  • 0330050 EP 08/13/1989
  • 0352713 EP. 01/13/1990
  • 0361817 EP 04/13/1990
  • 3628573 DE 02/13/1988
  • 1461877 GB 01/13/1977

International Class

C07D 219/04

Abstract

This invention is directed to novel nucleophilic polysubstituted aryl acridinium esters and to novel conjugates thereof. The novel nucleophilic polysubstituted aryl acridinium esters and novel conjugates thereof are useful in biological assays, including novel assays for the determination of Vitamin B12, folate, cortisol, estradiol, and thromboxane B2.

Other References

  • Hammond, et al., Jrnl. of Bioluminescence and Chemiluminescence, vol. 6, pp. 35-43 (1991)
  • "Organic Chemistry", 3rd ed., Hendrickson, et al., McGraw-Hill Book Co., New York, (1970), p. 71
  • "Advanced Organic Chemistry", 3rd ed., Mar., John Wiley & Sons, New York, (1985), pp. 304-310, 587
  • User Manual for DNA/RNA Synthesizer, published by Applied Biosystems, Inc., Foster City, Calif. (1990) pp. iii-vii, 6-1 to 6-21
  • User Manual on "DNA Modification Reagents for Use in Automated DNA Synthesis, published by Clontech Laboratories, Inc.", Palo Alto, Calif. pp. 2-3
  • Martinet et al. Bull. Soc. Chim. Fr. vol. 45 pp. 101-109 (1929)
  • Meek et al. J. Chem. Eng., Data vol. 14, pp. 388-391 (1969
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