Fertility enhancement

Patent 5240922 Issued on August 31, 1993. Estimated Expiration Date:

December 27, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Inventor

O'Neill, Christopher

Assignee

Northern Sydney Area Health Service

Application

No. 778879 filed on 12/27/1991

US Classes:

514/77, Inner salt (e.g., betaine, etc.)514/82, Quinolinyl or isoquinolinyl (including hydrogenated)514/211.07, Nitrogen attached directly or indirectly to the ring nitrogen of the seven-membered hetero ring by acyclic nonionic bonding (e.g., Diltiazem, etc.)514/219, Polycyclo ring system having the seven-membered hetero ring as one of the cyclos514/220, Tricyclo ring system having the seven-membered hetero ring as one of the cyclos514/523Additional nitrogen other than cyano

Examiners

Primary: Cintins, Marianne M.
Assistant: Cook, Rebecca

Attorney, Agent or Firm

Lowe, Price, LeBlanc & Becker

International Classes

A01N 043/00
A01N 043/62
A01N 037/34

Foreign Application Priority Data

1989-05-05 AU

Abstract

The present invention relates to a method of enhancing implantation of an embryo within the uterus of a female mammal. The method comprises administering an amount of a PAF antagonist, effective to enhance implantation, to the mammal. The invention also relates to a method of increasing the level of PAF around an embryo in the uterus of a female mammal by administering an amount of a PAF antagonist sufficient to inhibit PAF catabolism. Desirably the PAF antagonist is administered together with PAF or a homologue or analogue thereof. The invention also provides compositions comprising a PAF antagonist together with PAF or a homologue or analogue thereof, and a process for preparing the same.

Other References

CA 112(13), Milligan et al, "Failure of platelet activating factor to induce decidualization . . . "
CA 109(21), Spinks et al, "Antagonists of embryo derived PAF prevent implantation . . . "
CA 110(9), O'Neill, "Composition and methods for fertility control using PAF . . . "
CA 108(25), Acker et al "Role of PAF in the oviplantation in the rat . . . "
Biology of Reproduction, "Effects of Indomethacin and ICI 46,474 Administered During Ovum Transport on Fertility in Rabbits", vol. 14, No. 4, May 1976, pp. 451-457
Acta Endocrinologica, "Prostaglandin E2: Analysis of Effects on Pregnancy and Corpus Luteum in Hamsters and Rats", vol. 71, supplement 170, 1972, pp. 3-3