Haptens and tracers for immunoassays for propoxyphene
Patent 5239086 Issued on August 24, 1993. Estimated Expiration Date: 
July 29, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 29, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesPolypeptide propoxyphene derivatives for immunoassay reagents Patent #: 4025501 InventorsApplicationNo. 736890 filed on 07/29/1991US Classes:549/223, Xanthene ring system having a benzene ring bonded directly thereto para to the xanthene ring oxygen, wherein the carbon of a -COO- group is bonded directly to the benzene ring ortho to its position of attachment to the xanthene ring system, and spirolactone derivatives thereof (e.g., fluoresceins, chlorofluorans, etc.)560/173, Cyclic alcohol moiety560/177, Aldehyde group in acid moiety560/194Plural rings in alcohol moietyExaminersPrimary: Raymond, Richard L.Attorney, Agent or FirmInternational ClassC07D 311/86AbstractDisclosed is a substantially optically pure hapten, useful in an immunoassay for dextropropoxyphene and/or nordextropropoxyphene. The hapten corresponds to a specified structural formula (IX).Also disclosed is an immunogen derived from the hapten as well as an antibody raised in response to an immunogen derived from the hapten.Also disclosed is a fluorescent tracer derived from a substantially optically pure compound corresponding to the hapten, the tracer being useful in an immunoassay for dextropropoxyphene and/or nordextropropoxyphene.Also disclosed is an improved immunoassay for determining dextropropoxyphene and/or nordextropropoxyphene in a biological sample involving a step of contacting the sample with antibodies raised in response to the immunogen. Also disclosed is a fluorescence polarization immunoassay (FPIA) for determining dextropropoxyphene and/or nordextropropoxyphene involving a step of contacting the sample with antibodies raised in response to the immunogen, and/or involving a step of contacting the sample with a fluorescent tracer.Other References
Field of SearchXanthene ring system having a benzene ring bonded directly thereto para to the xanthene ring oxygen, wherein the carbon of a -COO- group is bonded directly to the benzene ring ortho to its position of attachment to the xanthene ring system, and spirolactone derivatives thereof (e.g., fluoresceins, chlorofluorans, etc.)Cyclic alcohol moiety Aldehyde group in acid moiety Plural rings in alcohol moiety |
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