U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Haptens and tracers for immunoassays for propoxyphene

Patent 5239086 Issued on August 24, 1993. Estimated Expiration Date: Icon_subject July 29, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Polypeptide propoxyphene derivatives for immunoassay reagents Patent #: 4025501
Issued on: 05/24/1977
Inventor: Leute

Inventors

Application

No. 736890 filed on 07/29/1991

US Classes:

549/223, Xanthene ring system having a benzene ring bonded directly thereto para to the xanthene ring oxygen, wherein the carbon of a -COO- group is bonded directly to the benzene ring ortho to its position of attachment to the xanthene ring system, and spirolactone derivatives thereof (e.g., fluoresceins, chlorofluorans, etc.)560/173, Cyclic alcohol moiety560/177, Aldehyde group in acid moiety560/194Plural rings in alcohol moiety

Examiners

Primary: Raymond, Richard L.

Attorney, Agent or Firm

International Class

C07D 311/86

Abstract

Disclosed is a substantially optically pure hapten, useful in an immunoassay for dextropropoxyphene and/or nordextropropoxyphene. The hapten corresponds to a specified structural formula (IX).Also disclosed is an immunogen derived from the hapten as well as an antibody raised in response to an immunogen derived from the hapten.Also disclosed is a fluorescent tracer derived from a substantially optically pure compound corresponding to the hapten, the tracer being useful in an immunoassay for dextropropoxyphene and/or nordextropropoxyphene.Also disclosed is an improved immunoassay for determining dextropropoxyphene and/or nordextropropoxyphene in a biological sample involving a step of contacting the sample with antibodies raised in response to the immunogen. Also disclosed is a fluorescence polarization immunoassay (FPIA) for determining dextropropoxyphene and/or nordextropropoxyphene involving a step of contacting the sample with antibodies raised in response to the immunogen, and/or involving a step of contacting the sample with a fluorescent tracer.

Other References

  • "Measurement of Dextropropoxyphene and Nordextropropoxyphene in Biological Fluids", by R. J. Flanagan et al., Human Toxicol, 3, 103S-114 S (1984)
  • "Detection of Methadone and Propoxyphene in Stored Tissue", by M. G. Fransioli et al., Journal of Analytical Toxicology, vol. 4, Jan./Feb. 1980, pp. 46-4
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