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US Patent 5237064 - Process for producing 7ଲ-substituted-aza-5댚ndrostan-3-ones

US Patent Issued on August 17, 1993
Estimated Patent Expiration Date: Icon_subject May 20, 2012Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

Described is a new process for producing 7ଲ-substituted-4-aza-5଱-androstan-3-ones and related compounds which are 5଱-reductase inhibitors.

Other References

  • Endo., vol. 91, No. 2, pp. 427-437 (1972) by Neri, et al., "A Biological Profile of a Non-steroidal Antiandrogen, SCH 13521 . . . "
  • Steroids, 14, 269-283 (1969), by Nayfeh, et al., "Metabolism of Progesterone by Rat Testicular Homogenates-III"
  • J. Pharm. Sci., 62, No. 4, pp. 638-640 (1973) by Doorenbos and Solomons, "Synthesis & Antimicrobial Properties of 17 Beta-Isopentyloxy-4-Aza-5 Alpha-Androstane and the 4-Methyl Derivative"
  • J. Pharm. Sci., 60, No. 8, pp. 1234-1235 (1971) by Doorenbos and Brown, "4.17 Alpha-Dimethyl-4-Aza-5 Alpha-Androstan-17 beta-ol Acetate & Related Azasteroids"
  • J. Pharm., 63, No. 4, pp. 620-622 (1974) by Doorenbos and Kim, "Synthesis & Evaluation of Antimicrobial Properties of Amidinoazaandrostanes and Guanidinoazaandrostanes"
  • J. Med. Chem. (1986) 29(11): pp. 2298-3115 by Rasmusson, et al., "Aza Steroids: Structure-Activity Relationships . . . "
  • The Prostate (1986) 9(1): pp. 65-75 by Brooks, et al., "Prostatic Effects Induced in Dogs By . . . 5 alpha-Reductase Inhibitors"
  • Steroids (1986) 47(1): pp. 1-19 by Brooks, et al., "5 Alpha-Reductase Inhibitory . . . Activities of Some 4-Aza-Steroids in the rat"
  • Endocr. (1985) 117(2); pp. 571-579, by Liang, et al., "Species Differences in Prostatic Steroidal 5 Alpha-Reductases of Rat. Dog and Human"
  • J. Med. Chem. (1984) 27(12): pp. 1690-1701, by Rasmusson, et al., "Azasteroids as Inhibitors of Rat Prostatic 5 alpha-reductase"
  • Chem. Abstracts, vol. 95, 109055j, by T. Liang, et al. "Inhibition of 5 Alpha-Receptor Binding . . . by a 4-Methyl-4-Aza-Steroid"
  • JNCl, vol. 74, No. 2, pp. 475-481 (Feb. 1985), by N. Kadohama, et al., "Ratardation of Prostate Tumor Progression in the Noble Rat by 4-Methyl-4-Aza-Steroidal Inhibitors of 5 Alpha-Reductase"
  • The Prostate, vol. 10, pp. 189-197 (1987) by G. Andriole, et al., "The Effect of 4MA . . . on the Growth of . . . Human Tumors . . . "
  • J. Endocr., vol. 57, pp. 111-121 (1973) by K. D. Bingham, et al., "The Metabolism of Testosterone by Human Male Scalp Skin"
  • Bioinorganic Chemistry, 17, pp. 372-376 (1986) by B. W. Metcalf, et al., "Patent Inhibition of Human Steroid . . . by 3-Androstene-3-Carboxylic Acid"
  • Biochemistry, 1990, vol. 29, pp. 2815-2824, by M. A. Levy, et al., "Inhibition of Rat Liver Steroid 5 Alpha-Reductase . . . "
  • J. Med. Chem., 1990, vol. 33, pp. 943-950, by D. A. Holt, et al
  • J. Steroid Biochem., vol. 34, Nos. 1-6, pp. 571-575 (1989), by M. A. Levy, et al., "Interaction Between Rat Prostatic 5 Alpha-Reductase . . . "
  • J. Med. Chem., vol. 33, pp. 937-942 (1990) by D. A. Holt, et al., "Steroidal A Ring Aryl Carboxylic Acids"
  • TIPS, Dec. 1989, vol. 10, pp. 491-495, by D. W. Metcalf, et al., "Inhibitors of . . . 5 Alpha-Reductase in Benign Prostatic Hyperplasia . . . "
  • Steroids, vol. 35, No. 3 (Mar. 1980) pp. 1-7, by L. Murphy, et al., "Effect of Estradiol on a . . . Binding Protein in the Uterus of the Mouse"
  • Prostate, vol. 9, pp. 311-318 (1986) by N. Stone, et al., "Estrogen Formation in Human Prostatic Tissue . . . "
  • Lancet, No. 1986, No. 8515, pp. 1095-1096, by F. Labrie, et al. "Combination therapy in prostate cancer"
  • J. Clin. Endocrin. and Metab., vol. 55, No. 1, pp. 188-193 (1987), by R. Rittmaster, et al., "The Effects of . . . a 5 Alpha-Reductase Inhibitor . . . "
  • J. Clin. Endocrin and Metab., vol. 74, No. 2, pp. 345-350 (1990), by A. Diani, et al, "Hair Growth Effects of Oral Administration of Finasteride . . . "
  • J. Clin. Endocrinol. Metab. 67, No. 4, pp. 808-816 (1988), by N. Bruchovsky, et al., "Kinetic Parameters of 5 Alpha-Reductase Activity in Stroma & Epithelium of Normal Hyperplastic, & Carcinomatous Human Prostates"
  • J. Steroid Biochem. 26, (3) pp. 349-353 (1987), by R. Hudson, "Comparison of Nuclear 5 Alpha-Reductase Activities in the Stromal and Epithelial Fractions of Human Prostatic Tissue"
  • J. Biol. Chem. 251, (19) pp. 5895-5900 (1976), by R. J. Moore, et al., "Steroid 5 Alpha-Reductase in Cultured Human Fibroblasts"
  • J. Biol. Chem. 264 (27) pp. 16249-16255 (1989), by S. Andersson, et al., "Expression Cloning & Regulation of steroid 5 alpha-Reductase, an Exzyme Essential for Male Sexual Differentiation"
  • Proc. Nat'l Acad. Science 87, pp. 3640-3644 (1990), by S. Andersson, et al., "Structural & Biochemical Properties of cloned and expressed human and rat steroid 5 alpha-reductases"
  • Nature 354, pp. 159-161 (Nov. 14, 1991), by S. Andersson, et al., "Deletion of Steroid 5 Alpha-Reductase-2 Gene in Male Pseudohermaphroditism"
  • Biol. of Reproduction, vol. 46, pp. 168-173 (1992), by J. D. Wilson, "Syndromes of Androgen Resistance"
  • J. Cancer Res. Clin. Oncol. 118, pp. 50-55 (1992), by A. Geldof, et al., "Consideration of the Use of . . . 4MA . . . in Prostate Cancer Therapy"
  • The Prostate 18, pp. 215-227 (1991), by J. Brooks, et al., "Effect of Castration, DES, Flutamide, and MK-906 on Growth of the Dunning Rat Prostatic Carcinoma . . . "
  • Eur. J. Pharm. 183(5), p. 1757 (1990), by Y. Masubuchi, et al., "Lack of DHT Inhibition . . . by Treatment of 4MA . .

Inventors

Assignee

Application

No. 886049 filed on 05/20/1992

US Classes:

546/14, Silicon containing540/2, Cyclopentanohydrophenanthrene ring system containing546/77The six-membered hetero ring shares ring members with one other cyclo only

Field of Search

546/77, The six-membered hetero ring shares ring members with one other cyclo only546/14, Silicon containing540/2Cyclopentanohydrophenanthrene ring system containing

Examiners

Primary: Daus, Donald G.

Attorney, Agent or Firm

US Patent References

2227876, 3239417, 3264301, 3285918, 4139619, 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth
Issued on: 02/13/1979
Inventor: Chidsey, III4220775, Preparation of 4-aza-17-substituted-5଱-androstan-3-ones useful as 5଱-reductase inhibitors
Issued on: 09/02/1980
Inventor: Rasmusson ,   et al.4317817, Novel steroid 5଱-reductase inhibitors
Issued on: 03/02/1982
Inventor: Blohm ,   et al.4377584, 4-Aza-17ଲ-substituted-5଱-androstan-3-one-reductase inhibitors
Issued on: 03/22/1983
Inventor: Rasmusson ,   et al.4596812, Methods and solutions for treating male pattern alopecia
Issued on: 06/24/1986
Inventor: Chidsey, III ,   et al.4732897, Steroidic 5଱-reductase inhibitors
Issued on: 03/22/1988
Inventor: Cainelli ,   et al.4760071, 17ଲ-N-monosubstituted carbamoyl-4-aza-5଱-androst-1-en-3-ones which are active as testosterone 5଱-reductase inhibitors
Issued on: 07/26/1988
Inventor: Rasmusson ,   et al.4845104, Oxidized analogs of 17ଲ-N-monosubstituted-carbamoyl-4-aza-5-଱-androstan-3-ones
Issued on: 07/04/1989
Inventor: Carlin ,   et al.4859681, 17 ଱-Acyl-4-aza-5a-androst-1-en-3-ones as 5 alpha-reductase inhibitors
Issued on: 08/22/1989
Inventor: Rasmusson ,   et al.4882319, Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-଱-reductase
Issued on: 11/21/1989
Inventor: Holt, et al.4888336, Steroid 5-alpha-reductase inhibitors
Issued on: 12/19/1989
Inventor: Holt, et al.4910226, Steroid 5-alpha-reductase inhibitors
Issued on: 03/20/1990
Inventor: Holt, et al.504956217ଲ-acyl-4-aza-5଱-androst-1-ene-3-ones as 5଱-reductase inhibitors
Issued on: 09/17/1991
Inventor: Rasmusson, et al.

Foreign Patent References

  • 970692 CA. 07/22/1975
  • 0004949 EP. 10/22/1979
  • 0155096 EP. 09/22/1985
  • 0200859 EP. 11/22/1986
  • 0277002 EP. 06/22/1988
  • 0289327 EP. 11/22/1988
  • 0314199 EP. 05/22/1989
  • 0343954 EP. 11/22/1989
  • 0375344 EP. 06/22/1990
  • 0375345 EP. 06/22/1990
  • 00375347 EP. 06/22/1990
  • 0375349 EP. 06/22/1990
  • 1465544 FR. 11/22/1965
  • WO91/12261 WO. 02/22/1990

International Class

C07J 073/00

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