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US Patent 5235522 - Method and apparatus for automated analysis of biological specimens

US Patent Issued on August 10, 1993
Estimated Patent Expiration Date: Icon_subject October 10, 2010Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

An apparatus and method for analyzing the cell objects of a cell sample for the diagnosis and treatment of actual or suspected cancer is disclosed. An image of the cell sample is first digitized and morphological attributes, including area and DNA mass of the cell objects are automatically measured from the digitized image. The measured attributes are compared to ranges of attribute values which are preestablished to select particular cell objects having value in cancer analysis. After the selection of cell objects, the image is displayed to an operator and indicia of selection is displayed with each selected cell object. The operator then reviews the automatically selected cell objects, with the benefit of the measured cell object attribute values and accepts or changes the automatic selection of cell objects. In a preferred embodiment, each selected cell object is assigned to one of six classes and the indicia of selection consists of indicia of the class into which the associated cell object has been placed. The measured DNA mass of identified cell object fragments in tissue section samples may also be increased to represent the DNA mass of the whole cell object from which the fragment was sectioned.

Inventor

Assignee

Application

No. 595117 filed on 10/10/1990

US Classes:

702/19, Biological or biochemical356/39, BLOOD ANALYSIS382/133Cell analysis, classification, or counting

Field of Search

436/10, Particle count or volume standard or control (e.g., platelet count standards, etc.)436/63, BIOLOGICAL CELLULAR MATERIAL TESTED356/39BLOOD ANALYSIS

Examiners

Primary: Teska, Kevin J.

Attorney, Agent or Firm

US Patent References

3833796, 4097845, Method of and an apparatus for automatic classification of red blood cells
Issued on: 06/27/1978
Inventor: Bacus
4125828, Method and apparatus for automated classification and analysis of cells
Issued on: 11/14/1978
Inventor: Resnick ,   et al.
4199748, Automated method and apparatus for classification of cells with application to the diagnosis of anemia
Issued on: 04/22/1980
Inventor: Bacus
4404683, Blood cell identification and classification system
Issued on: 09/13/1983
Inventor: Kobayashi ,   et al.
4523278, Method of automatic detection of cells and determination of cell features from cytological smear preparations
Issued on: 06/11/1985
Inventor: Reinhardt ,   et al.
4656594, Operator-interactive automated chromosome analysis system producing a karyotype
Issued on: 04/07/1987
Inventor: Ledley
4661913, Apparatus and method for the detection and classification of articles using flow cytometry techniques
Issued on: 04/28/1987
Inventor: Wu ,   et al.
4741043, Method of and an apparatus for image analyses of biological specimens
Issued on: 04/26/1988
Inventor: Bacus
4833629, Apparatus for categorizing and accumulating events
Issued on: 05/23/1989
Inventor: Moore
4987539, Apparatus and method for multidimensional characterization of objects in real time
Issued on: 01/22/1991
Inventor: Moore, et al.
5018209, Analysis method and apparatus for biological specimens
Issued on: 05/21/1991
Inventor: Bacus
5023785Hematology - diagnosis apparatus employing expert system technology
Issued on: 06/11/1991
Inventor: Adrion, et al.

International Classes

G06K 009/00
G06F 015/00

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