Sustained released delivery system for use in the periodontal pocket

Patent 5230895 Issued on July 27, 1993. Estimated Expiration Date:

July 27, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Photographic apparatus for use in making printing plates
Patent #: 4180320
Issued on: 12/25/1979
Inventor: McCollough

Composition and method for the preventative treatment of dental disease and apparatus for dispensing said composition
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Pharmaceutical preparation for remedy of periodontal disease and process for production thereof
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Intra-pocket drug delivery devices for treatment of periodontal diseases
Patent #: 4764377
Issued on: 08/16/1988
Inventor: Goodson

Periodontal disease treatment system
Patent #: 4919939
Issued on: 04/24/1990
Inventor: Baker

Method of and compositions for treating destructive periodontal disease Patent #: 4933172
Issued on: 06/12/1990
Inventor: Clark, Jr., et al.

Inventors

Assignee

Copley Pharmaceuticals, Inc.

Application

No. 517566 filed on 05/01/1990

US Classes:

424/422, Implant or insert424/424, Membrane or diffusion barrier424/426, Errodable, resorbable, or dissolving424/434, Mucosal (e.g., nasal, etc.)424/435, Mouth424/443, Web, sheet or filament bases; compositions of bandages; or dressings with incorporated medicaments424/444, Resorbable by the body424/456, Gelatin424/462, Containing solid synthetic polymers424/484, Matrices424/486, Synthetic polymer433/229, MISCELLANEOUS514/786, Glyceride514/944GEL

Examiners

Primary: Page, Thurman K.
Assistant: Azpuru, Carlos

Attorney, Agent or Firm

Lahive & Cockfield

Foreign Patent References

0429224A1 EP. 05/13/1991

International Classes

A61F 002/02
A61K 009/14
A61K 025/04
A61K 047/44

Abstract

An in vivo method is described for treating a subject for periodontal disease by placing a mixture of a glyceride composition and a therapeutic agent in the periodontal pocket of subject such that the therapeutic agent is released in a sustained manner. The glyceride composition is selected such that the mixture of the glyceride composition and the therapeutic agent is capable of forming a gel in the environment of the periodontal pocket. Also described is a sustained release delivery system comprising the mixture of the glyceride composition and therapeutic agent.

Other References

Eastman, "Sustained Release with Myverol 18-92 Distilled Monoglyceride", Publication No. 2FD-84, pp. 1-2, 1987
Eastman Publication No. ZM-1H, May 1988, entitled "Food Emulsifiers"
Deasy et al., J. Pharm. Pharmacol. 1989, 41:694-699 (Feb. 27, 1989), pp. 694-699
Larsen, T., J. Periodontol (Jan. 1990), pp. 30-34
Engstrom et al., Proceedings of the 15th International Symposium on Controlled Release of Bioactive Materials, Basel Aug. 15-19, 1988, pp. 105-106
Ericsson et al., Proceed. Intern. Sump. Control Rel. Bioact. Mater., 15 (1988), pp. 382-383
Landh et al., Emulsification of the Cubic Liquid Crystalline Phase in the Monoolein-Lecithin-Water System:, Publication date unknown
Engstrom, S., Lipid Technology vol. 2, No. 2 (Apr. 1990), pp. 42-45
Larsen, K., J. Phys. Chem. vol. 93, No. 21, 1989, pp. 7304-731