Methods and pharmaceutical compositions for treating episodic heartburn
Patent 5229137 Issued on July 20, 1993. Estimated Expiration Date: 
May 6, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 6, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMedicinal simethicone containing composition and its method of production Method and composition of reducing pain Rehydratable antacid composition Formulation with special 1,2-diacylglycero-3-phosphocholines for the treatment of gastrointestinal disorders Gastrointestinal compositions Fluidized magaldrate suspension Pharmaceutical compositions Artificial lower gastrointestinal valve Exogenously acidified antacid compositions having cytoprotective properties Pharmaceutical compositions InventorAssigneeApplicationNo. 879662 filed on 05/06/1992US Classes:424/687, Calcium carbonate424/690, Aluminum hydroxide424/692, Magnesium hydroxide or oxide424/717, Bicarbonate514/63, Silicon containing DOAI514/365, 1,3-thiazoles (including hydrogenated)514/370, Nitrogen bonded directly to ring carbon of the thiazole ring514/400, At imidazole ring carbon514/461, The hetero ring is five-membered514/819, ANTACID, ORAL514/820With antiflatulentExaminersPrimary: Waddell, Frederick E.Assistant: Henley, III, Raymond Attorney, Agent or FirmInternational ClassesA61K 033/10A61K 033/08 A61K 033/00 A61K 031/695 A61K 031/425 A61K 031/415 A61K 031/34 AbstractPharmaceutical medications and methods are disclosed for providing instant and sustained relief from pain or symptoms associated with episodic heartburn in humans. The medications consist essentially of antacids and histamine H2 -receptor antagonists, and may be administered on an as-needed basis in liquid or solid dosage forms. Typical antacids which may be used in combination with the histamine H2 -receptor antagonist are conventional antacids which are well known and widely used in the treatment of excess acid related gastrointestinal dysfunctions. Exemplary of typical antacids include, sodium bicarbonate, calcium carbonate, magnesium hydroxide and aluminum hydroxide, as well as commercially available high potency, flavored antacids. Histamine H2 -receptor antagonists which may be used in combination include those conventionally used in the treatment of peptic ulcers, such as, for example, cimetidine, ranitidine, famotidine and nizatidine. In carrying out the methods, an antacid and histamine H2 -receptor antagonist may be administered together as a single unitary dose in the form of a liquid or solid, or administered together, but separately as either liquids or solids or a combination thereof. The oral medications when formulated as a single unitary dose may include other additives, such as, for example, antiflatulents, flavorings, sweeteners and the like.Other References
Field of SearchOxide or hydroxideCalcium carbonate Aluminum, calcium or magnesium element, or compound containing Aluminum hydroxide Magnesium hydroxide or oxide Bicarbonate At imidazole ring carbon The hetero ring is five-membered With antiflatulent Silicon containing DOAI 1,3-thiazoles (including hydrogenated) Nitrogen bonded directly to ring carbon of the thiazole ring ANTACID, ORAL | |
