Stable hydrophilic acridinium esters suitable for liposome encapsulation
Patent 5227489 Issued on July 13, 1993. Estimated Expiration Date: 
January 22, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 22, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3352791 3689391 Polysubstituted aryl acridinium esters Polysubstituted aryl acridinium esters Process for forming liposomes Chemiluminescent acridinium labelling compounds Proteted chemiluminescent labels Process for stabilizing liposomes Polysubstituted aryl acridinium esters Patent #: 5110932 InventorsAssigneeApplicationNo. 826186 filed on 01/22/1992US Classes:546/23, Polycyclo ring system having the six-membered hetero ring as one of the cyclos424/450, Liposomes435/5, Involving virus or bacteriophage436/172, With fluorescence or luminescence534/751, Hetero ring containing534/798, Plural carbocyclic rings bonded directly to the azo group546/102, Acridines (including hydrogenated)546/104, Nitrogen, other than as nitro or nitroso, attached directly or indirectly to the acridine ring system by nonionic bonding546/107Plural nitrogens, other than as nitro or nitroso, attached directly to the carbocyclic rings of the acridine ring system (e.g., 3,6-diaminoacridines, etc.)ExaminersPrimary: Daus, Donald G.Attorney, Agent or FirmForeign Patent References
International ClassC07D 219/04AbstractA method for the detection of an analyte in a fluid sample using liposomes encapsulating acridinium esters (lumisomes). Hydrophilic polysubstituted aryl acridinium esters are useful as chemiluminescent markers and can be encapsulated within liposome vesicles without significant leakage of the esters from the vesicles. The lumisomes can be coupled to molecules with biological activity, such as antigens, antibodies, and nucleic acids, and used in luminescent assays.Other References
Field of SearchAcridines (including hydrogenated)Nitrogen, other than as nitro or nitroso, attached directly or indirectly to the acridine ring system by nonionic bonding Plural nitrogens, other than as nitro or nitroso, attached directly to the carbocyclic rings of the acridine ring system (e.g., 3,6-diaminoacridines, etc.) Polycyclo ring system having the six-membered hetero ring as one of the cyclos Hetero ring containing Plural carbocyclic rings bonded directly to the azo group |
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