Pulsatile drug delivery device using stimuli sensitive hydrogel
July 30, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3710795 Blood and tissue detoxification apparatus Osmotically driven fluid dispenser Device having variable volume chamber for dispensing useful agent Dispenser with diffuser Biodegradable, implantable drug delivery device, and process for preparing and using the same Device for delivering drug to certain pH environments Osmotic capsule Dosage system and method of using same Process for manufacturing dosage form InventorsApplicationNo. 737675 filed on 07/30/1991US Classes:604/892.1, Osmotic or diffusion pumped device or system424/422, Implant or insert424/457, Sustained or differential release514/965, Discrete particles in supporting matrix604/891.1Implanted dynamic device or systemExaminersPrimary: Thaler, Michael H.Assistant: Polutta, Mark O. Attorney, Agent or FirmForeign Patent References
International ClassA61K 009/22AbstractA device for the dispensing of a biologically active material into the surrounding environment is disclosed which consists of at least one wall enclosing a compartment which contains a swollen stimuli sensitive hydrogel in which the biologically active material is entrained in solution. The hydrogel deswells or shrinks in response to contact by external physical or chemical stimuli releasing the biologically active material into the portion of the compartment previously occupied by the swollen hydrogel. The wall enclosing the compartment is rigid and contains means allowing the passage of the biologically active material from the compartment to the surrounding environment and also for transmitting the external stimuli to the swollen hydrogel in said compartment. The wall may contain orifices or be permeable to the active material and external stimuli depending upon the drug and the stimuli to be used. The hydrogel reversibly deswells, shrinks or contracts in response to stimuli, such as temperature, pH, ionic strength, glucose concentration or metabolites in the body and then reswells and reentrains active material not diffused from the compartment when the stimuli is removed. The wall may consist of one or more layers which, in combination, provide for the expeditious delivery of the active substance either through permeation through the wall or through orifices in the wall and also for the conducting of the external stimuli through the wall into the compartment to trigger the deswelling of the hydrogel.Other References
Field of SearchCONTROLLED RELEASE THERAPEUTIC DEVICE OR SYSTEMImplanted dynamic device or system Osmotic or diffusion pumped device or system Capsules (e.g., of gelatin, of chocolate, etc.) Gelatin Sustained or differential release Implant or insert Surgical implant or material Synthetic polymer GEL SHAPED FORMS ADAPTED FOR NONINGESTIBLE USE OTHER THAN SUPPOSITORY TYPE (E.G., FILMS, INSERTS, ETC.) CAPSULE (E.G., GELATIN, ETC.) Discrete particles in supporting matrix | |
