U.S. patents available from 1976 to present.
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Antibacterial 3-(fused-ring substituted)phenyl-5ଲ-amidomethyloxazolidin-2-ones

Patent 5225565 Issued on July 6, 1993. Estimated Expiration Date: Icon_subject April 23, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Re29607

3641152

5-Halomethyl-3-phenyl-2-oxazolidinones
Patent #: 4128654
Issued on: 12/05/1978
Inventor: Fugitt ,   et al.

Novel 5-hydroxymethyl oxazolidinones, the method of preparing them and their application in therapeutics
Patent #: 4250318
Issued on: 02/10/1981
Inventor: Dostert ,   et al.

3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents
Patent #: 4340606
Issued on: 07/20/1982
Inventor: Fugitt ,   et al.

P-Oxooxazolidinylbenzene compounds as antibacterial agents
Patent #: 4461773
Issued on: 07/24/1984
Inventor: Gregory

Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
Patent #: 4705799
Issued on: 11/10/1987
Inventor: Gregory

Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
Patent #: 4801600
Issued on: 01/31/1989
Inventor: Wang ,   et al.

Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
Patent #: 4965268
Issued on: 10/23/1990
Inventor: Wang, et al.

Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
Patent #: 4977173
Issued on: 12/11/1990
Inventor: Brittelli, et al.

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Inventor

Assignee

Application

No. 872871 filed on 04/23/1992

US Classes:

548/229Chalcogen bonded directly at 2-position of the oxazole ring

Examiners

Primary: Daus, Donald G.

Attorney, Agent or Firm

Foreign Patent References

  • 892270 BE. 08/13/1982
  • 127902 EP. 06/13/1984
  • 184170 EP. 11/13/1985
  • 0316594 EP 05/13/1989

International Class

C07D 263/20

Abstract

The present invention relates to 3-(fused-ring substituted)phenyl-5ଲ-amidomethyloxazolidin-2-one (XXI) ##STR1## where either R2 and R4 is --H and the other of R2 and R4 taken together with R3 is --(CH2)n5 --CH=CH--(CH2)n6 --. Also claimed are various alkyl substituted fused ring substituted alkanones, preferred is 3-(1'-oxo-2'଱/ଲ-methyl-5'-indanyl)-5ଲ-(acetamidomethyl)oxa zolidin-2-one. These compounds are useful as antibacterial agents.

Other References

  • Ioli et al Chem. Abstr. vol. 103 entry 160009b (1985)
  • Beilsteins Handbuch vol. 145, 4 Aufl XXVII
  • Slee, A. M. et al., Oxazolidinones, a New Class of Synthetic Antibacterial Agnets: In Vitro and In Vivo Activities of DuP 105 and DuP 721, Antimicrobial Agnets and chemotherapy, vol. 31 (No. 11): 1791-1797 (Nov. 1987
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